CD146及CD31在乳腺组织中的表达及与临床病理学特征的关系.docVIP

CD146及CD31在乳腺组织中的表达及CD146的表达及CD31标记的微血管密度(MVD)与乳腺癌的关系。 方法：采用免疫组化SP法检测20例乳腺正常组织及136例乳腺癌组织中CD146蛋白的表达及微血管计数，并分析其与临床病理学特征的关系。 结果：在20例正常组织中，CD146表达率为100%(20/20)，136例乳腺癌病例中CD146蛋白在肿瘤细胞表达阳性率为33.1% (45/136)。在肿瘤细胞中，CD146蛋白表达与组织学分级成正相关(P0.01)，与ER.,PR的表达成负相关(P0.01)。CD146在三阴性乳腺癌中表达高于其他类型乳腺癌(P0.05)。CD146的表达与患者年龄，肿瘤大小，淋巴结转移，HER-2状态无明显相关关系。 在肿瘤间质中，CD146的表达与组织学分级，淋巴结转移，肿瘤细胞中CD146的表达成正相关(P0.05)，与ER，PR的表达成负相关(P0.05)。 肿瘤微血管密度与淋巴结转移，组织学分级，病理学分期，HER-2状态成正相关。 肿瘤间质中CD146的表达与患者年龄，肿瘤大小，HER-2状态无明显相关关系。 肿瘤细胞CD146的表达与间质CD146的表达成正相关(P0.05)。 在肿瘤间质中，CD146的表达与CD31(微血管密度)表达成正相关(P0.01)。 结论： CD146表达和微血管的形成在乳腺癌的发生、浸润和转移中起重要作用。检测CD146蛋白的表达和MVD有助于判断病情程度及预后，CD146有望成为治疗乳腺癌的新靶点。 【关键词】乳腺癌, CD146, 微血管密度, 免疫组化 Expression of CD146 and CD31 in Invasive Breast Carcinoma: correlation with clinico-pathological features CHANG wenlong, ZHAO jing, ZHANG bingxin. (the First Hosiptal of Baoding, Hebei Baoding 071000) Abstract Purpose: The aim of this study was to evaluate the role of CD146 and microvessel density (MVD) by CD31 in invasive ductal carcinoma of the breast. Methods: 20 cases of normal breast tissues and 136 cases of invasive ductal carcinoma, not otherwise specified (IDC-NOS) were studied in parallel by immunohistochemistry SP method for CD146 and microvessel density (MVD) measured by an anti-CD31 antibody of the tumors. Results: CD146 was positively expressed in all of the normal tissues. The expression rates of CD146 proteins in breast carcinoma was 33.1% (45/136), CD146 expression in tumor cells was positively correlated with histological grade, and P53 expression, negatively with ER, PR status in IDC-NOS (P0.01). CD146 was over expressed in triple negative breast cancer (P0.01). No correlation was found between the tumor cell expression of CD146 and patient year, tumor size, lymph node metastasis and HER-2 status. CD146 expression in tumor stroma was positively correlated with lymph node metastasis, histological grade, pTNM stage in IDC-NOS. MVD was positively correlated with lymph node metastasis,