文献_2011-Patients with endometriosis and patients with poor ovarian reserve have abnormal follicle stimulating.pdfVIP
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Patients with endometriosis and patients with poor
ovarian reserve have abnormal follicle-stimulating
hormone receptor signaling pathways
a ~ a b
Rebeca Gonzalez-Fernandez, M.Sc., Oscar Pena, M.Sc., Jairo Hernandez, Ph.D.,
a,c b,d a,c
Pablo Martın-Vasallo, M.D., Ph.D., Angela Palumbo, M.D., Ph.D., and Julio Avila, Ph.D.
a b
Departamento de Bioquımica y Biologıa Molecular, Universidad de la Laguna, Centro de Asistencia a la Reproduccion
c
Humana de Canarias, La Laguna, Instituto de Tecnologıas Biomedicas, Universidad de La Laguna, Tenerife, Spain; and
d Department of Obstetrics and Gynecology, New York University, New York, New York
Objective: To study the integrity of the FSH receptor (FSHR) signaling pathway in granulosa-lutein cells at the
time of egg retrieval and its relationship with the infertility diagnosis.
Design: In vitro assays.
Setting: University laboratory and private IVF center.
Patient(s): Patients undergoing IVF: 35 controls (no ovarian factor, NOF), 28 poor responders (PR), 32 patients
with endometriosis (EM), and 22 patients with polycystic ovary syndrome (PCOS).
Intervention(s): Quantitative reverse transcriptase-polymerase chain reaction (PCR) in granulosa-lutein cells from
pooled follicles.
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