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Genome
Assembly
Introduction
denovo
Liu Weiqing
liuweiqing@genomics.org.cn
Nov 25th 2013
BackgroundBackground
t
n
e Data filter
t
n K-mer analysis
o Error Correction
C
Assembly
Assembly Evaluation
2
Background
What is the genome?
Genome Estimated
Organism
Size Genes
Human (Homo sapiens) 3 billion 30,000
Laboratory mouse
2.6 billion 30,000
(M.musculus)
Mustard weed (A. thaliana) 100 million 25,000
Fruit fly (D. melanogaster) 137 million 13,000
3
Background
How to sequence the genome bases?
read1
read2
44
Background
What the data format we use to assemble?
555
Background
t
n
e Data filter
t
n K-mer analysis
o Error Correction
C
Assembly
Assembly Evaluation
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