加味柴芍六君颗粒对溃疡性结肠炎患者TNF-α影响及疗效观察.pdf

2.4 统计学分析 ·············································25 3 结 果 ···················································25 3.1 临床疗效 ···············································25 3.2 内镜下粘膜疗效变化·····································27 3.3 血清TNF-α 浓度变化 ·····································28 3.4 随诊疗效及不良反应比较 ··································28 4 讨论及分析 ·············································28 结 论 ··················································36 参考文献 ··················································37 附 录 ··················································41 综 述 ··················································43 致 谢 ··················································48 攻读学位期间发表的学术论文目录 ·······················49 作者声明 ··················································50 个人简历 ··················································51 中 文 摘 要 目 的：观察加味柴芍六君颗粒(jwcslj)对溃疡性结肠炎 （UC ）患者的 临床疗效及对血清肿瘤坏死因子- α（TNF-α ）水平的影响，从基础和临 床研究方面系统探讨该方的作用机制。 方 法：本研究共观察符合诊断标准的溃疡性结肠炎患者60例，均来 自于广西中医学院第一附属医院门诊与病房。所有病例按就诊先后顺序 随机分为治疗组和对照组各30例。中药治疗组给予加味柴芍六君颗粒， 每日一付，早晚分服。对照组给予柳氮磺胺吡啶片口服, 每次1g，每日4 次。疗程均为8周，对比观察两组患者治疗前后症状评分、血清TNF-α （ELISA法）的变化及临床疗效。 结 果：治疗组30例，显效12例，有效16例，无效2例，总有效率93.3%， 对照组30例，显效8例，有效15例，无效7例，总有效率76.7%。两组经统 计学分析 （Ridit分析，P ＜0.05 ），治疗组总有效率优于对照组。治疗前后 症状评分比较，治疗组在改善患者单项症状方面优于对照组 （t检验，P ＜0.05 ）；治疗后两组患者血清TNF-α水平与治疗前比较，均有所降低， 差异有统计学意义 （P ＜0.05 ）；但治疗后治疗组TNF-α水平明显低于对照 组 （P ＜0.05 ）。加味柴芍六君颗粒能够有效缓解患者腹痛、腹泻、里急后 重、脓血便等症状，疗效显著而确切，明显优于传统的西医柳氮磺胺吡 啶治疗方法。 结 论：加味柴芍六君颗粒是治疗溃疡性结肠炎的有效方药，它可以 明显改善UC 患者的临床症状，修复和保护结肠粘膜，具有调节血清TNF-α 水平的功能，可能是其治疗UC 的机制之一，值得进一步的研究和开发。 关键词：溃疡性结肠炎；肿瘤坏死因子；加味柴芍六君颗粒 1 Observation of clinical curative effect of JiaWeiChaiShaoLiuJun granule for Ulcerative Colitis and the change of TNF-α ABSTRACT Objective: To observe the clinical effect of treating ulcerative colitis (UC) with