IGF-1在大鼠肝纤维化过程中的动态变化及扶正化瘀方对肝纤维化的影响.pdf

13 目 录 Y19008 中文摘要 …………………………………………………………………1 英文摘要…………………………………………………………………5 研究论文IGF．1在大鼠肝纤维化过程中的动态变化及扶正化瘀方对肝 纤维化的影响 引言 ……···……·········…···……···…···…………···…………···12 第一部分IGF。1在实验性大鼠肝纤维化自发逆转过程中的动态变化 前言………………………………···………………………………14月IJ舌 “””一“””“…“”””““””一”““””“”“”“”“…””…“一14 材料与方法…………………………………………………………14 结果…·…-··…···…·········…··…·········…·…········……···……18 附图 …······…·············…·…·······…···…····…········…·········22 附表····…·····················································-·······…····33 讨论····························…··········…·······…··········…········35 刀、结 ································································……·····39 参考文献……………………………………………………………39 第二部分扶正化瘀方对实验性肝纤维化及肝组织IGF．1的影响 前言………………………………………………………………···42目lJ吾 ”””““”””””””””…”“”””””“”””一”“一一…”“”一’42 材料与方法…………………………………………………………42 结果 …························………········…·…·····…····………··．43 附图 ···········…··········…······…·······································46 附表…………………···…………………………………………--·51 讨论···········································································53 小结 …······…········-·········……······……………······………···56 参考文献……………………………………………………………56 结论 …········…·…··-······………········…·…············…···…···58 综述胰岛素样生长因子．1在肝脏疾病中的研究……………………59 致谢·················…····················…·············…······…·············71 个人简历…………………………………………………………………72 ／ 中文摘要 IGF．1在大鼠肝纤维化过程中的动态变化及扶正化瘀方 对肝纤维化的影响 摘 要 发肝脏炎症及肝组织自我修复的一个复杂的病理过程。该过程致使细胞外 基质 extracellular 内过度沉积形成肝纤维化，甚则肝硬化。在肝纤维化形成的过程中，细胞 stellate 因子起了关键性的作用。肝星状细胞 h印atic cell，HSC 是分泌各种 细胞因子和产生ECM的主要细胞，HSC的激活、增殖是肝纤维化形成的 关键环节。在HSC增殖、活化及合成ECM的肝纤维化过程中，多种细胞 因子如转化生长因子B facto卜B