CD147在肿瘤细胞入侵中作用.pdf

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CD147在肿瘤细胞入侵中作用.pdf

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Available online at Experimental and Molecular Pathology 83 (2007) 283 – 295 /locate/yexmp Review CD147 immunoglobulin superfamily receptor function and role in pathology Kathryn T. Iacono, Amy L. Brown, Mark I. Greene, Sandra J. Saouaf ⁎ University of Pennsylvania, Department of Pathology and Laboratory Medicine, 252 John Morgan Building, 36th Hamilton Walk, Philadelphia, PA 19104-6082, USA Received 24 August 2007 Available online 7 September 2007 Abstract The immunoglobulin superfamily member CD147 plays an important role in fetal, neuronal, lymphocyte and extracellular matrix development. Here we review the current understanding of CD147 expression and protein interactions with regard to CD147 function and its role in pathologic conditions including heart disease, Alzheimer’s disease, stroke and cancer. A model linking hypoxic conditions found within the tumor microenvironment to upregulation of CD147 expression and tumor progression is introduced. © 2007 Elsevier Inc. All rights reserved. Keywords: CD147; EMMPRIN; MMP; MCT; Immunoglobulin superfamily; Integrin; Tumor; Metastasis Contents Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 283 Structural organizati