心房颤动与血管紧张素-1转换酶基因多态性相关性的研究.docVIP

心房颤动与血管紧张素-1 转换酶基因多态性的相关性研究 王淑敏 2张萍 *1陈凤荣 1张幼怡 1杜丽娟 1赵京丹 1王丛 【关键词】心房颤动 ；血管紧张素－1转换酶基因 ；插入/缺失多态性 【摘要】 目的 探讨血管紧张素-1 转换酶（ACE）基因I/D多态与心房颤动的相关性。方法 采用多聚酶链反应（PCR）的方法对183例北京地区汉族病例进行I/D多态性检测，包括孤立性房颤53例，高血压房颤32例，高血压患者38例，健康对照50例。结果 孤立性房颤组、高血压房颤组、高血压The study on the association between the insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) gene and lone atrial fibrillation . Wang shumin1, Zhang ping2,Chen fengrong1, 1 (Department of Cardiovascular Diseases, Peking university third hospital,Beijing 100083, China;E-mail: zhp1024@);2(Department of Cardiovascular Diseases, Peoples Hospital of Peking University, Beijing, 100044, China) 【Key words】 lone atrial fibrillation ACE gene I/D polymorphism 【Abstract】 Objective The study was conducted to investigate the association between the insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) gene and lone atrial fibrillation .Methods A case-control study was performed on 183 subjects,including 53 subjects with lone atrial fibrillation, 32 subjects with atrial fibrillation and essential hypertension,38 subjects with essential hypertension and 60 healthy controls.The I/D polymorphism of the ACE gene was identified by polymerase chain reaction (PCR).Results There was no significant differenece in the allele frequency or the genotype frequency of the I/D polymorphism of the ACE gene between all the observed groups, and the equable distribution of the I/D allele in different groups was not influenced by age and sex. Conclusion There was no evidence for the association between the insertion/deletion (I/D) polymorphism and lone atrial fibrillation . 心房颤动是一种最常见的心律失常，可引起血栓栓塞及心衰等严重并发症，并可使病死率增高。房颤可以散发，也可呈家族聚集性发病，提示其发生存在遗传学基础。目前，对其分子遗传学机制的探讨正成为医学界研究的热点。 心肌纤维化是房颤发生的重要机制，血管紧张素-1 转换酶（ACE）作为肾素－血管紧张素－醛固酮系统的环节之一，与心肌纤维化及心肌重构有着密切关系，已证明，血管紧张素-1 转换酶抑制剂（ACEI）可通过降低心房压力和减轻左房扩大，使慢性二尖瓣反流患者反流减轻，减少房颤的发生，因而ACE基因可能为心房颤动的候选基因之一[1]。 本文旨在探讨ACE基因I/D多态性位点在孤立性房颤、高血压房颤、高血压及健康对照中分布的差异，进一步了