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Journal of Southeast University English Edition Vol.30 No.1 pp.122 127 Mar.2014 ISSN 1003—7985 Bayesian analysis for mixed-effects model defined by stochastic differential equations 1 2 4 2 4 3 4 1 Yan Fangrong Zhang Ping Lu Tao Lin Jinguan 1 Department of Mathematics Southeast University Nanjing 210096 China 2 Department of Mathematics China Pharmaceutical University Nanjing 210009 China 3 Laboratory of Molecular Design and Drug Discovery China Pharmaceutical University Nanjing 210009 China 4 State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing 210009 China Abstract The nonlinear mixed-effects model with stochastic developed. differential equations SDEs is used to model the population Nonlinear mixed-effects modeling NONMEM has pharmacokinetic PPK data that are extended from ordinary been proved to be a kind of widely used and effective tool differential equations ODEs by adding a stochastic term to for describing the pharmacokinetic PK and pharmaco- the state equation.Compared with the ODEs the SDEs can dynamic PD properties of drugs 1 2 .The flexibility of model correlated residuals which are ubiquitous in actual modeling correlation structures with the total variation pharmacokinetic problems. The Bayesian estimation is separated into inter-and intra-individual variation contrib- provided for nonlinear mixed-effects models based on utes to the rapidly growing quantity of nonlinear mixed- stochastic differential equ

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