大肠癌生物治疗临床应用的研究进展.pdfVIP

大肠癌生物治疗临床应用研究进展 1△ 1 1 1 2 12 刘涛 ，沈杰 ，何凤 ，张丹 ，项方 ，卢斌 1 400037 2 （第三军医大学新桥医院肿瘤生物治疗中心，重庆 ； 上海恒润生物医疗技术研 究所，上海200336 ） Research progress on colorectal cancer biology treatment in clinical application Liu Tao△, Shen Jie, He Feng, Xiang Fang, Lu Bin 1 Department of Center For Cancer Biotherapy Of XinQiao Hospital, Third Military Medical （ University, Chongqing 400037, China ；2 Shanghai Hengrun bio-technology research institute, shanghai 200336, China ） Abstract Colorectal cancer is one of the most common gastrointestinal malignant tumor in our 【 】 country, with the improvement of peoples living standard, there is an upward trend in the incidence and mortality of colorectal cancer. In recent years, with the rapid development of biotechnology, the research in colorectal cancer gene therapy, immune therapy such as biological therapy research increasingly grow in quantity, obtained some results in clinical; Become the fourth treatments after the surgery, radiotherapy and chemotherapy treatments, more and more get the wide attention of people. In this paper, the molecular target therapy for colorectal cancer, gene therapy, cell immunotherapy summarized research progress on clinical application. key words Colorectal cancer; biological treatment; clinical application 【 】 【指示性摘要】大肠癌是我国最常见的消化道恶性肿瘤之一，随着人们生活水平 的提高，大肠癌的发病率和死亡率呈逐年上升趋势。近年来，随着生物技术的快 速发展，针对大肠癌所进行的基因治疗、免疫治疗等生物治疗研究日趋增多，在 临床上取得一定的成果；成为继手术、放疗、化疗后的第四种治疗手段，越来越 受到人们的广泛重视。本文对大肠癌的分子靶向治疗、基因治疗、细胞免疫治疗临 床应用研究进展进行综述。 【关键词】大肠癌；生物治疗；临床应用 R735 A 【中图分类号】 【文献标识码】 大肠癌(colorectal cancer，CRC)包括结肠癌和直肠癌，是临床上最常见的消 化道恶性肿瘤之一。手术切除是治疗大肠癌最有效、最重要的手段；但是，大肠 癌的起病隐匿，早期无特殊的临床表现，所以当大肠癌患者发现时多为进展期。 25%