纳米羟基磷灰石_聚酰胺66修复肢体良性骨缺损疗效观察.pdfVIP

. . 中国骨肿瘤骨病2011年12月第10卷第６期 Chin J Bone Tumor Bone Disease, December 2011, Vol 10, No.6 568 . 临床论著 . 纳米羟基磷灰石/聚酰胺66修复肢体良性骨缺损 的疗效观察 张斌　段宏　杨红胜　邹昌　李鸿　严永刚　屠重棋 作者单位：610041 成都，四川大学华西医院骨科 通讯作者：段宏 【摘要】　目的　初步评估和分析纳米羟基磷灰石/聚酰胺66 (nano-hydroxyapatite polyamide 66，n-HA/ PA66)修复良性骨肿瘤术后骨缺损的疗效和安全性。方法　2007年11月至2010年12月，应用n-HA/PA66骨填充材 料修复114例良性骨肿瘤术后骨缺损，肿瘤刮除、灭活及人工骨植入70例，28例加用内固定，16例加用异体骨 板和内固定。结果　除10例失随访外，104例获得随访，随访时间3-33个月，平均8.2个月。伤口均I/甲愈合，无 １例发生切口感染、非特异炎症反应和排斥反应；术前、术后的血常规、免疫、肝、肾功能检查均无明显异 常。Ｘ线和CT检查示：术后１个月，病灶区密度逐渐升高，可见植骨周围与自体骨结合处模糊，少量新生骨痂 形成；术后３个月，病灶区从颗粒植骨周围间隙开始向中心融合成片，更多新生骨痂影融合；术后６个月，病 灶区密度明显升高，病灶区大量新生骨痂形成。骨愈合时间为术后2-6个月，３个月时植骨愈合率65%，６个月 为96.2％。结论　n-HA/PA66骨填充材料的生物相容性良好，无明显排斥反应和非特异炎症反应，修复囊性良 性骨肿瘤和瘤样病变效果良好。 【关键词】　羟基磷灰石类；酰胺类；骨代用品；骨肿瘤；骨疾病 doi:10.3969/j.issn.1671-1971.2011.06.008 Preliminary observation on the effectiveness of nano-hydroxyapatite/polyamide 66 in repairing bone defect due to benign bone tumor ZHANG Bin, DUAN Hong, YANG Hongsheng, et al. Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PRC Abstract Objective To evaluate and analyse the effect and safety of nano-hydroxyapatite/polyamide 66 【 】 (n-HA/PA66) in repairing bone defects due to benign bone tumors. Methods From November 2007 to December 2010, bone defects due to benign bone tumors in 114 patients were filled with the n-HA/PA66. Benign bone tumors underwent the curettage, inactivation measures and then the tumor cavities were filled up with the artificial bone in 70 cases. Of all the patients, 28 cases were placed internal fixation and 16 were placed both variant bone plates and internal fixation. Results The follow-up of 10 patients was lost. 104 patients obtained follow-up. The mean follow-up period was 8.2 months (range; 3-33 months). Al