白藜芦醇对重症急性胰腺炎大鼠血液流变学影响实 验的研究.pdfVIP

白藜芦醇对重症急性胰腺炎大鼠血液流变学影响的实 验研究 董剑达,金洲祥,朱少俊 (温州医学院附属第二医院普通外科, 温州, 325027) 摘要 目的:观察白藜芦醇(resveratrol,Res)对重症急性胰腺炎(severe acute pancreatitis,SAP)大鼠血液流变学的影响。方法: 36只大鼠随机分为假手术组、 SAP组、Res治疗组 (Res ,10mg/kg) 3组,每组12只。各组大鼠于制模后6h剖杀, 检测各组大鼠的血液流变学指标,红细胞脆性及胰腺病理学检查。结果: SAP组大 鼠全血粘度,血浆粘度及红细胞压积均显著升高,红细胞脆性增加；红细胞沉降率 和纤维蛋 原降低。而Res组以上各项指标均显著 改善，差异有统计 学意义 (P0.05)。结论: Res能有效改善SAP大鼠血液流变学异常,保护胰腺组织。 [关键词]：重症急性胰腺炎; 白藜芦醇; 血液流变学; 大鼠 [中图分类号]：R657.51 Experimental studies on effects of resveratrol on hemorrheologic alternation of rats with experimental severe acute pancreatitis DONG Jianda, JIN Zhouxiang, ZHU Shaojun.Department of General Surgery, the second affliated hospital of Wenzhou medical college, Wenzhou,Zhejiang , 325027, China. Corresponding author:Zhouxiang Jin,E-mail:jzx0847＠ ABSTRACT: Objective To investigate the effect of resveratrol(Res) on hemorrheologic alternation of rats with severe acute pancreatitis. Methods 36 rats were divided into three groups: control group, SAP model group and Res treated group. Rats were sacrificed at 6h after inducing SAP model. The pathological changes of pancreas were observed under light microscope. Blood samples were obtained from SAP rats for hemorrhelogic examination. Results Blood viscosity, 资金项目：浙江省教育厅留学回国基金资助（2005-01） 通信作者：金洲祥，E-mail:jzx0847＠ 1 PDF 文件使用 pdfFactory 试用版本创建 plasma viscosity,hematocrit were significantly elevated,while erythrocyte sedimentation rate and fibrinogen were decreased significantly in SAP rats compared with sham operation group.But the parameters of Res group were amelioration.