高效铜催化多组分反应合成喹啉-2(1H)-氨.pdfVIP

Copper-Catalyzed Highly Efficient Multicomponent 1 Reactions:Synthesis of quinolin-2(1H)-imine She Debing, Yang Mingyu, Hui Haohao, Zhao Qin, Chen Min, Huang Guosheng* State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou （730000 ） E-mail ：hgs2368@163.com Abstract A variety of substituted quinolin-2(1H)-imine are prepared via a copper-catalyzed multicomponenet reaction of sulfonyl azides, terminal alkynes, and o-aminobenzaldehyde. First sulfonyl azides, alkynes under the copper catalysis condition build the intermediate, then o-aminobenzaldehyde dehydrogenation under Et3N condition and attact the intermediate to form the quinolin-2(1H)-imine. Keywords: sulfonyl azides, alkynes, o-aminobenzaldehyde, multicomponent reactions, quinolin-2(1H)-imine The prominence of quinolin-2(1H)-one in natural product sand biologically active molecules has promoted considerable efforts toward their synthesis1. As a “privileged” scaffold, quinolin-2(1H)-one shows interesting biological properties2 . A number of quinolin-2(1H)-one possess interesting biological activity, including anticancer, antifungal, and anti-HIV activities. Quinolin-2(1H)-one derivatives quinolin-2(1H)-imine also have been reported to be a type of anticancer, antifungal, and anti-HIV active compounds. Multicomponent reactions (MCRs) involving a domino process with at least three different simple substrates have emerged as a powerful strategy3.This methodology allows molecular complexity and diversity