手性吲哚啉衍生物合成方法研究进展.pdfVIP

DOI: 10.6023/cjoc1111293 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 手性吲哚啉衍生物合成方法的研究进展 张宝乐a 秦 伟b 段迎超a 余 斌a 张 恩a 刘宏民*,a a 郑州大学药学院 郑州 450001 b 齐齐哈尔医学院药学院 齐齐哈尔 161000 摘要 吲哚啉衍生物广泛存在于自然界中, 因具有多种生物学活性而引起广泛关注. 近年来, 手性吲哚啉衍生物成为 此领域的研究热点, 也报道了多种相应的合成方法, 主要包括动力学拆分、不对称合成、手性合成子策略等, 不对称 Domino 级联反应作为近年来发展较快的领域, 也引起了广泛关注, 对以上合成方法加以综述. 关键词 吲哚啉; 不对称; 合成 Recent Development on the Synthetic Methods of Chiral Indoline Derivatives Zhang, Baolea Qin, Weib Duan, Yingchaoa Yu, Bina Zhang, Ena Liu, Hongmin*,a a School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001 b School of Pharmacy, Qiqihar Medical University, Qiqihaer 161000 Abstract The indoline skeletons, widely present in alkaloids and other products with diverse biological activities, which also have been considered as privileged structures due to their widespread use as building blocks and chiral auxiliaries in asymmet- ric synthesis. The importance of these motifs has determined that numerous synthetic multi-step strategies have been devel- oped. Consequently, there has been a continuing interest in the development of efficient methods to obtain enantioenriched substituted indolines. A lot of methods have been introduced, including dynamic kinetic resolution, asymmetric reactions,