中药复方对2 型糖尿病患者胰岛素抵抗和胰岛β 细胞功能的影响 赵美燕.docVIP

中药复方对2型糖尿病患者胰岛素抵抗和胰岛β细胞功能的影响 赵美燕1 顿晓熠2 郑瑞莲3 【摘要】目的：观察中药复方对2型糖尿病患者胰岛素抵抗和胰岛β细胞功能的影响。方法：将483名患者按照诊断标准分为五组，其中2型糖尿病治疗组（T2DM-T组）103名，糖耐量受损治疗组（IGR-T组）95名，2型糖尿病对照组（T2DM-C组）91名，糖耐量受损对照组（IGR-C组）88名，糖耐量正常组（NGT组）106名，治疗组采用中药复方治疗，阳性对照组口服二甲双胍。分别用胰岛素作用指数（IAI）及稳态模型评估的胰岛素抵抗指数（HOMA-IR）评价胰岛素敏感性，用早期胰岛素分泌指数（ΔI30/ΔG30）、修正的胰岛β细胞功能指数（MBCI）、基础胰岛素分泌功能指数（HOMA-β）以及葡萄糖处置指数（DI）评估胰岛β细胞功能。结果：各组治疗前与NGT组比较，T2DM组的IAI和HOMA-IR存在统计学差异；T2DM组和IGR组的ΔI30/ΔG30、MBCI、HOMA-β、DI四个指标均存在显著差异；各组治疗后与治疗前比较发现，T2DM组与IGR组的IAI显著升高，T2DM组的HOMA-IR显著降低，但是IGR组的HOMA-IR基本没有发生变化，差异无统计学意义；ΔI30/ΔG30、HOMA-β、DI三个指标均存在统计学差异，MBCI差异无统计学意义。 结论：中药复方具有降糖疗效，改善胰岛素敏感性，有效地缓解胰岛β细胞功能降低，调节糖脂代谢紊乱。 【关键词】2型糖尿病；中药复方；胰岛素抵抗；胰岛β细胞功能 Chinese herbal compound on insulin resistance in patients with type 2 diabetes and pancreatic β-cell function 【Abstract】 Objective: To observe the effect of compound on insulin resistance in patients with type 2 diabetes and pancreatic β-cell function. Methods: 483 patients divided into five groups according to diagnostic criteria, including type 2 diabetes group (T2DM-T group) 103, impaired glucose tolerance treated group (IGR-T group) 95 type 2 diabetic control group (T2DM-C group) 91, impaired glucose tolerance group (IGR-C group) 88, normal glucose tolerance (NGT group) 106, the treatment group were treated with traditional Chinese medicine treatment, the positive control group was treated with metformin. Respectively, with insulin index (IAI) and homeostasis model assessment insulin resistance index (HOMA-IR) evaluation of insulin sensitivity, with the early insulin secretion index (ΔI30/ΔG30), modified β-cell function index (MBCI), based insulin secretion index (HOMA-β) and glucose disposition index (DI) assessment of β-cell function. Results: The pre-treatment group compared with NGT, T2DM group of IAI and HOMA-IR statistical difference; T2DM group and the IGR group ΔI30/ΔG30, MBCI, HOMA-β, DI four indicators are significantly different; the group after treatment compared with before treatment found that, T2DM and