2型糖尿病论文：2型糖尿病 胰岛素抵抗 益气养阴活血祛痰.docVIP

2型糖尿病论文：2型糖尿病 胰岛素抵抗 益气养阴活血祛痰 【中文摘要】观察和验证自拟方剂祛胰抵方(以益气养阴、活血祛痰为治则)联合二甲双胍对改善气阴两虚兼血瘀痰滞型2型糖尿病患者胰岛素抵抗状态的疗效,为降低糖尿病及其并发症的发生率及死亡率提供新的思路及治疗方法。方法：将60例2型糖尿病胰岛素抵抗患者随机分为2组,在基础治疗相同的前提下,对照组给予二甲双胍片(山东科源制药有限公司)500mg,每日三次口服；治疗组给予二甲双胍片500mg,每日三次,以及益气养阴、活血祛痰中药汤剂,每日一剂,水煎两次共取药汁200ml,早晚两次分服。两组均以8周为一疗程。观察两组患者治疗前后胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(ISI)、空腹血糖(FPG)、餐后2小时血糖(2hPG)、空腹胰岛素(FINS)、糖化血红蛋白(HbAlc)、血脂分析(TC、TG、HDL-C、LDL)、中医证候积分的变化。结果：治疗组可明显减轻气阴两虚兼有血瘀痰滞型2型糖尿病胰岛素抵抗患者的胰岛素抵抗指数,升高胰岛素敏感指,降低血糖、糖化血红蛋白、血脂、中医证候积分等指标,且优于对照组；通过观测治疗前后血常规、尿常规、便常规、肝功、肾功、心电图等指标,显示治疗期间两组患者各指标均在正常范围内,未见异常变化。结论：益气养阴、活血祛痰中药联合二甲双胍疗法明显优于单独使用二甲双胍疗法,可以更明显降低HOMA-IR并升高ISI；降低FPG、2hPG、FINS、HbA1c;能明显降低患者TG、TC、LDL并升高HDL-C;降低2型糖尿病胰岛素抵抗患者的中医证候积分,且无明显不良反应及毒副作用,安全性较好。 【英文摘要】Purpose:To observe and Prove the use of YiQiYangYin HuoXueQuTan TCM(QuYiDiFang) union metformin in improving the IR state of T2DM patients with IR, and to offer a new way of thinking and treatment in order to lower the incidence and death rate of DM and its complication.Methods:60 patients with insulin resistance of type 2 diabetes were randomly divided into two groups, On the premise of same basic, therapy group give metformin slice (shandong keyuan pharmaceutical Co., LTD.) 500mg, three times daily; The treatment group gives metformin slice 500mg, three times daily, and yiqi yangyin huoxue qutan Chinese medicine, water frying twice total take a medicine juice 200ml, sooner or later, two times daily. 8 weeks as one period of treatment..Observe both groups of patients before and after the treatment of insulin resistance index (HOM-IR), insulin sensitivity index (ISI), fasting plasma glucose (FPG) and 2-hour plasma glucose (2hPG), fasting insulin (FINS), glycated hemoglobin Alc (HbAlc), Chinese medicine clinical symptom scores.Results:Qi and blood expectoranting traditional Chinese medicine combined metformin treatment significantly better than single metformin treatment, we can be more obviously decrease HPMA-IR and increase ISI; Reduce 2hPG, FINS, and FPG HbAlc; Can obviously red