血液及其相关制剂在特护病房、重病房应用.ppt

SY Huang 血液及其相关制剂在特护病房、重病房的应用 台大医院 黄圣懿 医师 大纲说明 药(病生)理机转 临床应用 实证效果 Single organ failure Severe sepsis Complication Severe Sepsis: New Concepts in Pathogenesis and Management Cytotoxic effects of microorganisms Endothelial injury response Coagulation (thrombosis) Inflammation Drotrecogin Alfa (Activated) XigrisR Recombinant human activated protein C Mechanisms MTD Adverse effects Clinical trials Pharmacoecnomics Drotrecogin Alfa (Activated): Mechanisms Recombinant Human Activated Protein C (rhAPC) High risk of death APACHE II 25 Sepsis-induced multiple orga