薄荷油_环糊精聚合物微球包合物的制备与表征.pdfVIP

中草药 Chinese Traditional and Herbal Drugs 第 42 卷 第 2 期 2011 年 2 月 • 271 • 薄荷油-β-环糊精聚合物微球包合物的制备与表征 * 李仲谨，杨 威 ，陈玉苗，丁金皓，韩春鹏 陕西科技大学 教育部轻化工助剂化学与技术重点实验室，陕西 西安 710021 摘 要：目的 优选薄荷油 β-环糊精聚合物（β-CDP ）微球包合的最佳工艺。方法 采用饱和水溶液法制备薄荷油 β-CDP 微球包合物，通过 L 4 9 (3 )正交试验设计以回归分析法为指标对制备工艺进行了优化；分别用红外光谱、综合热分析和 X 射 线衍射分析法对薄荷油 β-CDP 微球包合物进行表征。结果 最佳制备工艺条件是选定 A B C D ；影响因素的大小依次为： 2 2 1 3 β-CDP 微球和与水之比＞β-CDP 微球和薄荷挥发油投料比＞包合温度＞包合时间；IR 、XRD 、TGA 等方法证明了包合物的 生成。结论 薄荷油的包合方法合理可行。 关键词：薄荷油；β-环糊精聚合物微球；红外光谱；X 衍射；热重分析 中图分类号：R286.02 文献标志码：A 文章编号：0253 - 2670(2011)02 - 0271 - 04 Preparation and characterization of peppermint oil-β-cyclodextrin polymer microsphere inclusion compound LI Zhong-jin, YANG Wei, CHEN Yu-miao, DING Jin-hao, HAN Chun-peng Key Laboratory of Auxiliary Chemistry Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science Technology, Xi’an 710021, China Abstract: Objective To optimize the including preparation for peppermint oil-β-cyclodextrin polymer (β-CDP) microsphere inclusion compound. Methods Peppermint oil-β-CDP microsphere inclusion compound was prepared by using co-precipitation. The preparation process was optimized through the L 4 9(3 ) orthogonal test design and regression analysis. Peppermint oil-β-CDP microsphere inclusion compound was characterized by infrared (IR) spectroscopy, thermogravimetric analysis (TGA), and X-ray diffraction (XRD). Results The best technological condition was A B C D , and the order of the influence factors was the proportion 2 2 1 3 of β-CDP microsphere and water the percentage of peppermint oil in β-CDP microsphere inclusion temperature incl