依立雄胺对经尿道前列腺切除术后肉眼血尿的治疗作用.pdfVIP

Original Articles Chin J Evid-based Med 2008, 8(12): 1051-1052 依立雄胺对经尿道前列腺切除术后 肉眼血尿的治疗作用 邓  华  郭志明  龚春雨  赖  飞 成都市第二人民医院泌尿外科（成都 610017 ） 摘要  目的 评价依立雄胺对经尿道前列腺切除（TURP ）术后肉眼血尿的治疗作用。方法 将TURP 术后发 生肉眼血尿的患者按入院顺序分为两组，试验组25 例除常规对症处理外，服用依立雄胺5 mg bid ，3 个月，对照组 25 例仅常规对症处理。结果 随访6 个月后，试验组的肉眼血尿复发率（30% ）明显低于对照组（63% ），且试验组 的复发肉眼血尿分级也明显低于对照组（P0.05 ）。结论 依立雄胺可有效减少TURP 术后肉眼血尿的发生。 关键词 肉眼血尿；经尿道前列腺切除术；依立雄胺 Effect of Epristeride on Gross Hematuria Secondary to Transurethral Resection of Prostate DENG Hua, GUO Zhi-ming, GONG Chun-yu, LAI Fei Department of Urology, The Second People’s Hospital of Chengdu, Chengdu 610017, China Abstract Objective To evaluate the effect of epristeride on gross hematuria secondary to transurethral resection of prostate (TURP). Methods A total of 50 patients with gross hematuria secondary to TURP were divided into two groups: 25 patients were treated with routine treatment plus 5 mg epristeride, twice a day for 3 months, while the other 25 only received routine treatment. Results At the 6-month follow-up visit, gross hematuria recurred in 63% of patients in the control group, but in only 30% of patients in the epristeride group. The difference was statistically significant (P0.05). Moreover, the grade of gross hematuria was significantly lower in the epristeride group (P0.05). Conclusion Epristeride appears to be effective in treating gross hematuria secondary to TURP. Key words Hematuria; Transurethral resection of prostate; Epristeride 良性前列腺增生（BPH ）是泌尿外科的常见疾 相关报道。本试验通过使用依立雄胺治疗TURP 术 病，经尿道前列腺切除术（TURP ）是目前最常见 后肉眼血尿来观察其作用。 的手术方式，但术后肉眼血尿常常是患者反复就 1 对象与方法 诊的首要原因。近年研究表明，非那雄胺可抑制 [1,2] 1.1 研究对象 增生前列腺组织中的血管生成 ，从而减少继发 [3,4] 1.1.1 纳入标准 TURP 术后6 个月内因发生肉眼 于BPH 的肉眼血尿 。非那雄胺是一种竞争性 II 型5α- 还原酶抑制剂，它可以抑制睾酮转化为双 血尿而就诊的患者。