生物活性陶瓷材料设计基于反应骨组织再生.pdfVIP

J. R. Soc. Interface (2009) 6, S349–S360 doi:10.1098/rsif.2008.0419.focus Published online 20 January 2009 REVIEW Bioactive ceramic-based materials with designed reactivity for bone tissue regeneration Chikara Ohtsuki1,*, Masanobu Kamitakahara2 and Toshiki Miyazaki3 1Department of Crystalline Materials Science, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Naogya 464-8603, Japan 2 Graduate School of Environmental Studies, Tohoku University, 6-6-20, Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan 3 Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu-ku, Kitakyushu 808-0196, Japan Bioactive ceramics have been used clinically to repair bone defects owing to their biological affinity to living bone; i.e. the capability of direct bonding to living bone, their so-called bioactivity. However, currently available bioactive ceramics do not satisfy every clinical application. Therefore, the development of novel design of bioactive materials is necessary. Bioactive ceramics show osteoconduction by formation of biologically active bone-like apatite through chemical reaction of the ceramic surface with surrounding body fluid. Hence, the cont