中药致肝损害110例分析.pdfVIP

中药致肝损害110例分析 * 徐国荣（南阳医学高等专科学校第一附属医院，河南南阳 473058） 中图分类号 R595.4；R969.3 文献标志码 A 文章编号 1672－2124（2014）06－0563－03 摘 要 目的：分析中药致肝损害的临床特点及用药特点。方法：对某院110例中药致肝损害患者的年龄、性别、用药类型、用药 时间、给药途径、剂量、病理类型、临床表现进行分析。结果：中药致肝损害以中年女性为多见；以治疗风湿、类风湿、乳腺病、白发、 脱发类药物常见；症状以胃肠道症状为主，占83.64％；病理分型以肝细胞型为主，占70.91％。肝损害的发生与给药时间过长、用 药剂量过大、剂型等有很大关系。结论：应加强中药合理用药指导，避免超长时间、超大剂量用药，并正确选择给药途径，以提高用 药的安全性、合理性和有效性，防止肝损害发生。 关键词 中药；肝损害；合理用药 Traditional Chinese Medicine-induced Hepatic Lesion ：Analysis of 110 Cases XU Guo-rong（The First Affiliated Hospital of Nanyang Medical College ，Henan Nanyang 473058，China） ABSTRACT OBJECTIVE ：To analyze the clinical characteristics and medication characteristics of traditional Chinese medicine- induced hepatic lesion. METHODS ：A total of 110patients with liver traditional Chinese medicine-induced hepatic lesion in our hos- pital were analyzed with regard to patients ’age ，gender ，types of drugs used ，duration ，route and dosage of administration ，patho- logical types and clinical manifestation ，etc. RESULTS ：The traditional Chinese medicine-induced hepatic lesion occurred more of- ten in middle-aged women ；the traditional Chinese medicines were mainly used for rheumatism ，rheumatoid arthritis ，breast dis- ease ，leukotrichia and hair loss ；the symptoms of gastrointestinal symptoms took the lead with 83.64％；liver cell type was the ma- jor pathological type ，accounting for 70.91％. The hepatic lesion was closely related to prolonged administration ，overdosage and dosage forms. CONCLUSIONS ：We should strengthen the guidance on rational use of traditional Chinese medicine ，avoid its pro- longed administration and overdosage and correctly choose the route of administration to improve medication safety ，rationality and effectiveness and prevent traditional Chinese medicine-induced hepatic lesion. KEYWORDS Traditional Chinese medicine ；Liver lesion ；Rational use of dr