异丙酚与瑞芬太尼靶控输注应用于肥胖人群的研究进展.pdfVIP

匡!匿鏖醴量复蒸苤查!Q!!生!!旦筮33鲞筮!!塑!咝』△!型!旦!!塑：堕!!!墅!笪!!!!：!!!．!!：丛垡!1 763 ·综述· 异丙酚与瑞芬太尼靶控输注应用于肥胖人群的 研究进展 何娟王琛谢红 【摘要】背景近年来，肥胖人群不断增加，肥胖本身及其并发症使得肥胖患者经历手术的概率增加，其围术期处理对麻 醉医师提出了挑战。短效、迅速的麻醉药物联合应用是全凭静脉麻醉的发展趋势，其中异丙酚和瑞芬太尼药物组合在短小手术 中有其优越性。运用靶控输注(target-controlled 血浆浓度。 目的探讨异丙酚与瑞芬太尼TCI用于肥胖人群的可行性及前景。内容阐述肥胖对静脉麻醉药物使用的影 响，根据近年发表文献分析异丙酚与瑞芬太尼TCI系统在肥胖人群中运用的可行性。趋向有待开发出更适合肥胖人群的 药代动力学模型，从而更好地满足临床。 【关键词】麻醉，静脉；肥胖症；哌啶类；二异丙酚；药物疗法，计算机辅助；药物代谢动力学；评价研究 An of infusionof and／orremifentanilinobese HE NG updatetarget-controlledpropofol pafients Juan+，WAChen，XIE Second 215004，China Hong． DepartmentofAnesthesiology，theAffiliatedHospitalofSoochowUneni可，Suzhou Obese is inrecent of becauseof 【Abstract】Backgroundpeople，whoincreasing years，hashigherprobabilitysurgery itselfand／orits bea for useof obesity complications．Itsperioperativemanagementmay majorchallenge narcoticisthe trendoftotalintravenousanesthesia．Theco-administrationof and rapid-onset，short-actingdrugs development propofol remifentanilhas inshort canadministerata manyadvantagessurgeries．Target-controlledinfusion(TCI)systemsdrugs specific amoreaccurateandstable To the and of concentration．Objective concentration，ensuring target investigatefeasibilityprospects TClwith andremifentanilinobese Theeffectsof Oilintravenousanestheticswereelaborated． propofol subjects．Contentobesity The ofTCl andremifentanilin tothe with obese was literatures． feasibility propofol acc