服用他汀类药物与慢性心力衰竭患者认知功能关系的研究.pdfVIP

‘221· 塞旦垫堑鱼堕鏖!!!!主箜!!鲞笙!塑堕!i!型堕!婴鳖Y垒!!￡!i!堡尘垦!里!堕i塑：!Q!!：y!!：!!，盟!：! 服用他汀类药物与慢性心力衰竭患者认知功能关系的研究 臧鸿斌，李晓东+ [摘要]目的探讨他汀类药物治疗对慢性心衰患者认知功能的影响。方法入选70例NYHAⅡ～IV 级、左室射血分数45％的慢性心衰患者为观察对象。其中连续服用他汀类药物3个月的35例慢性心衰患者进 StateExamina- 入他汀组，35例未服用他汀类药物的慢性心衰患者进入对照组。使用简易智能量表(Mini—Mental tion，MMSE)评估两组入选时及入选3个月后的认知功能情况。结果他汀组与对照组在筛选及3个月后随访 时，MMSE评分差异无统计学意义(P=0．78，P=0．77)；两组间随访前后认知功能障碍比率比较差异无统计学意 结论本研究未能发现他汀类药物可改善慢性心衰患者认知功能，提示短期服用他汀类药物不能改善慢性心衰 患者认知功能。 [关键词]慢性心功能衰竭；认知功能障碍；简易智能量表；他汀类药物 betweenstatins and functionin withchronic Relationship takingcognitive patients heartfailureZANG of ofChinaMedical Hong-bin，LIXiao．dong+(DepartmentCardiology，ShengjingHospital University，Shenyang110004．China) in withchronic To theeffectofstatins on function [Abstract]objectiveidentify takingcognitive patients heartfailure．Methods70 withchronicheart leftventricularfractions patients failure(NYHAⅡ～1V)，whoseejection werelowerthan45％．wereincluded．35whohad takenstatinsfor3monthswereenrolledinthe patients continuously statins theotherswhohadnottakenstatinswereenrolledinthecontrol Mini—Mental therapygroup，and group．Then State usedtoevaluethe functionatthetimeof andafter3monthsfol— Examination(MMSE)werecognition screening Therewasno differenceinMMSEscoresbetweenstatins andcontrol low—up．Results significant therapygroup group atthetimeof after3months