支气管肺泡灌洗液中3种肿瘤标志物的含量检测及意义_医学论文.docVIP

支气管肺泡灌洗液中3种肿瘤标志物的含量检测及意义_医学论文 支气管肺泡灌洗液中3种肿瘤标志物的含量检测及意义_医学论文 作者：黄芳，王香玲，荫斌霞，展淑琴 【关键词】 肺肿瘤 Clinical significance of determination of 3 tumor markers in bronchoalveolar lavage fluid 　　【Abstract】 AIM: To investigate the clinical value of 3 tumor markers ［carcinoembryonic antigen (CEA), cytokeratin19fragments (CYFRA211) and tissue polypeptide specific antigen (TPS)］ in bronchoalveolar lavage fluid (BALF) in patients with lung cancer. METHODS: The levels of CEA, CYFRA211 and TPS in serum and BALF were measured in 62 patients with lung cancer and 36 patients with benign lung disease by electrochemiluminescence (Elecys2010) and ELISA respectively. RESULTS: The levels of the 3 tumor markers measured in BALF were much higher in lung cancer group than that in benign lung disease group (0.05) and they were higher in patients in stage III and IV than those in stage I and II. The tumor markers increased to different degrees among the patients in various pathological classifications. It was also found that the levels of these tumor markers were higher and more sensitive in BALF than those in serum, especially in TPS. CONCLUSION: The measurement of the tumor markers in BALF is of more significant value than the measurement in serum, which helps the early diagnosis, pathological classification and prognosis evaluation of lung cancer. 　　【Keywords】 lung neoplasms bronchoalveolar lavage fluid tumor markers, biological 　　【摘要】 目的： 研究支气管肺泡灌洗液（BALF）中3种肿瘤标志物癌胚抗原(CEA)、细胞角蛋白片段211(CYFRA211) 、组织多肽特异性抗原（TPS）对肺癌的临床诊断意义. 方法： 采用电化学发光免疫分析仪法（Elecys2010）、酶联免疫吸附法分别检测62例肺癌患者、36例肺部良性病变患者血清及BALF中CEA和CYFRA 211，TPS的含量. 结果： 肺癌患者BALF中3种肿瘤标志物的含量明显高于肺部良性病变患者(0.05)，且随着TNM临床分期升高，肿瘤标志物的含量也明显升高. 在不同病理类型的肺癌中，3种肺癌肿瘤标志物升高的程度均有所不同. BALF中肿瘤标志物的含量与同期血清中的含量相比，出现更早且浓度更高，尤以TPS升高最为明显. 结论： BALF中3种肺癌标志物的检测在肺癌的早期诊断、病理类型的推断及预后判断方面都有一定的意义，其临床价值优于血清. 　　【关键词】 肺肿瘤；支气管肺泡灌洗液肿瘤标记，生物学 　 　　0引言 　　血清肿瘤标志物在肺癌中的应用已作过大量研究，表明肺癌患者血清中癌胚抗原(carcinoembryonic antigen, CEA)、细胞角蛋白片段211(CYFRA211)、 组织多肽特异性抗原（tissue polypeptide specific antigen, TPS）均较肺