精子形态与精液其他参数的关系及对体外受精结局的影响[J].docVIP

精子形态与精液其他参数的关系及对体外受精结局的影响 王凤英，李玉艳，何畏，俞炽阳，屈宗银，龙玲，李明舵 （400038重庆，第三军医大学西南医院妇产科） [摘要] 目的 了解精子形态在体外受精（in vitro fertilization，IVF)中的作用。方法 回顾性分析在本生殖中心接受常规IVF治疗的397个周期的精子正常形态率，分析其与精液参数的关系以及对IVF结局的影响。问题1：按正常形态率如何分组应在方法中有所提及；进行了形态学检查，胚胎培养也应在方法中简要提到。英文摘要也请作相应修改 结果 精子正常形态率与精液其他参数如精子密度、活率及前向运动精子比率（PMS）呈显著的正相关（r分别为0.188、0.197、0.190，P0.01），精子正常形态率、密度、活率及PMS与受精率均呈显著的正相关关系（r分别为0.237、0.171、0.155、0.187，P＜≤5%）、B组（5%B组≤14%）及C组（＞＜±7.54）%，明显低于临床妊娠组的（20.05±9.51）%（P＜±14.1）岁明显大于正常形态率＞±4.6）岁（P＜Relationship between sperm morphology and semen parameters and effects of normal form rates on IVF outcomes Wang Fengying,Li Yuyan, Qu Zongyin ,He Wei,Yu Chiyang,Long Ling,Li Mingduo (Department of Obstetric and Gynecology ,South-West Hospital ,Third Military Medical University, ChongQing,400038) [Abstract] Objective： to investigate the effects of sperm morphology in in vitro fertilization .Methods: Relationship between sperm morphology and semen parameters and effects of normal forms on IVF outcomes were analyzed from 397 IVF cycles. Results : sperm normal forms was significantly correlated with sperm density, motility, percentage of progressive motile sperm (PMS %), all P＜0.001.The normal form rate, density, motility and PMS % was positively related to the fertilization rates, P＜0.001. There were significant differences in the fertilization rates among sperm normal form s ≤5%、＞5%≤14% and ＞14% groups . The normal form rates from the group with no embryo transfer were markedly lower than those from the group with clinic pregnancy, P＜0.05. Patient age in ≤5% normal form group was significantly older compared with that in ＞14% normal form group( P＜0.05). Conclusion: The sperm morphology can affect fertilization rates of IVF , and may be a better predictive parameter for fertilization in IVF. The sperm normal forms will decrease with patient age. [Key words] IVF; semen parameter;sperm morphology; fertilization rate Corresponding author:WangFengying,Tel:86-23E-m