WorldHealthOrganizationSurveysofTransmittedandAcq：的世界卫生组织调查和采集传输.pptVIP

下载本文档

3
0
约 20页
2017-08-22 发布于重庆
举报
版权申诉

WorldHealthOrganizationSurveysofTransmittedandAcq：的世界卫生组织调查和采集传输.ppt

1、本文档共20页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

* * * World Health Organization Surveys of Transmitted and Acquired HIV Drug Resistance in Resource Limited Settings CROI 2011 S Bertagnolio*, K Kelley*, A Saadani Hassani*, Y Obeng-Aduasare**, M Jordan*° *World Health Organization, HIV Department, Geneva **Dartmouth College, NH, USA °Tufts University School of Medicine, MA, USA Goal of the WHO HIVDRSurveillance Strategy Standardized survey methods Inform population-based selection of 1st and 2nd line ART regimens Support national programs in minimizing the emergence and transmission of HIVDR Gilks et al. Lancet, 2006 Elements of the WHO HIVDRSurveillance Strategy Monitoring HIVDR Early Warning Indicators * at ART sites Surveillance of acquired HIVDR Surveillance of transmitted HIVDR *Jordan et al. Poster # 626; Poster Discussion Weds 1 pm Surveys of Acquired HIVDR Objectives To describe HIVDR in cohorts at start and 12 months after ART initiation To estimate viral load suppression 12 months after ART initiation at the clinic level Use results for programmatic adjustments Populations starting 1st line ART at sentinel clinics (naive and ARV exposed) Surveys of Acquired HIVDR Using WHO Methods (Feb 2011) 15 surveys conducted in 15 clinics in 5 countries Burundi, India, Malawi, Mozambique, Nigeria ~140 na?ve or ARV exposed adults or pediatric patients consecutively initiating first-line ART enrolled in each clinic Total of 2,150 patients surveyed, when data from the 15 surveys are combined N=2,150 Patients starting ART 1,448 (67.3%) Patients retained in care and alive at 12 months 128 Patients with viral load 1,000 c/ml (10%); all genotyped 1,150 Patients with viral load 1,000 c/ml (90%) 309 (14.4%) Lost to follow up 191 (8.9%) Transfer out 169 (7.9%) Died 26 (1.2%) Unclassifiable 6 (0.3%) Stopped 1 (0.05%) Switched to second line ART 1,503 (70%) Genotyped before ART initiation Acquired HIVDR Surveys Combined Analysis 1,278 Pa