间质干细胞及急性肺损伤.ppt

Mesenchymal Stem Cells and Acute Lung Injury 间质干细胞及急性肺损伤 ARDS was first recognized in the 1960s1 as a clinical syndrome of severe acute respiratory failure presenting with hypoxemia and bilateral pulmonary infiltrates, most often in the setting of pneumonia, sepsis, or major trauma. ARDS最初在1960年，被人们认识为严重急性呼吸衰竭的临床综合征； 血氧不足和双边肺浸润，通常继发于肺炎、败血症、或严重的的创伤； distinction between (ALI) and ARDS relates to the severity of hypoxemia, with the former having a PaO2/FiO2 of less than 300, the latter with a PaO2/FiO2 of less than 200. lung endothelial injury, alveolar epithelial injury, the accumulation