进展期霍奇金淋巴瘤的理想治疗方案.pdfVIP

· ·68 ·会议速递· 进展期霍奇金淋巴瘤的理想治疗方案 李义克晓燕 【摘要】 进展期霍奇金淋巴瘤(HL)是一种可以治愈的疾病。ABVD方案被认为是HL的标准治疗 方案，但是否需要联合放疗存在争议。PET、细胞与分子水平检测已成为分层治疗和疾病分级的重要提示 工具。新发现的一些治疗靶点在复发HL中非常有效，已尝试作为一线的治疗。进展期HL患者的治疗在 过去30年中取得了很大进展，但也显现出一些问题，如怎样才能提高治疗有效率而又能减轻短期和长期 的毒性等。就HL最合理的治疗方案、放疗对进展期HL的重要性、可否依据临床生理危险因素改变治疗 方案等进行介绍。 【关键词】霍奇金淋巴瘤；进展期；化学治疗 ofadvanced LI Optimaltherapy Hodgldn’SlymphomaYi，KEXiao—yan．DepartmentofHematology, Third PekingUniversityHospital,Be勺汛g100191，China author：KE CorrespondingXiao—yon，Emaikxiaoyank@yahoo．con S becomeacurablediseaseinthe of 【Abstract】Advanced-stageHodgkin7lymphoma(HL)has majority is to the debatescontinue theroleofradiation consideredbe standard regarding patients．ABVD therapy，but this ofinterim emission patientpopulation．Theincorporationpositron tomography(PE町 therapy(RT)in andcharacterizationofHLoncellularandmolecularlevelsare astoolsfortreatment imaging， emerging advances in stratificationand ofdisease overthe 3decadeshaveresulted predictors status．Therapeutic past the ofthe with HL． Several have when cureofthe majority patientsadvanced—stage questionsemerged whatconstitutes withabalancebetweena curerateand short— considering optimaltherapy hilgh minimizing and reviewfocuseson3 elements：whatisthe isthe long—termtoxicity．This key optimalchemotherapy?What basedonclinical risk be roleofradiation advanced