英语科普小知识 某家禽类益生菌能变换细胞层对付有害细菌.docVIP

A strain of?probiotic bacteria（益生菌）?that can fight harmful bacterial infections inpoultry（家禽）?has the ability to change its coat, according to new findings from the Institute of Food Research. The probiotic is currently being taken forward through farm-scale trials to evaluate how well it combats Clostridium perfringens -- a cause of?necrotic（坏死的）?enteritis in poultry and the second most common cause of food poisoning in the UK. ? The researchers at IFR, which is strategically funded by the Biotechnology and Biological Sciences Research Council, had previously found that the probiotic Lactobacillus johnsonsii, when given to young chicks, prevents the colonisation of C. perfringens. Now, in research published in the journal PLOS ONE, they have found that the probiotic bacteria have the ability to alter their coat. They speculate that this could be one way in which the probiotic outcompete C. perfringens.? ? The researchers noticed when examining the bacteria that a small number of them appear smooth. They identified genes responsible for making a special coat, or?slime（黏液，烂泥）capsule, which the bacteria surround themselves in. This protects the bacteria from stomach acids and?bile（胆汁，愤怒）?salts, and helps them come together to form biofilms. It may also protect against drying out when outside the host. The natural appearance of smooth mutants could be a?ploy（策略，活动）?used by the bacteria to introduce variation into its populations, making them able to take advantage of different environments. ? By turning off one or more of the coat genes, they could see what effect this had on its ability to stick to gut tissues. The next step is to understand the regulation of the genes involved in making the coat said Dr Arjan Narbad, who led the studies. We want to find out whether changing the coat affects the probiotics fitness to colonise and inhabit the gut. ? This in turn could prevent C. perfringens from colonising the gut. This competitive exclusion could be one reason why