英语科普小知识 失眠似与多动腿综合症有关联.docVIP

Johns Hopkins researchers believe they may have discovered an explanation for the sleepless nights associated with restless legs syndrome (RLS), a symptom that persists even when the disruptive, overwhelming?nocturnal（夜的）?urge to move the legs is treated successfully with medication. Neurologists have long believed RLS is related to a dysfunction in the way the brain uses the neurotransmitter?dopamine（多巴胺）, a chemical used by brain cells to communicate and produce smooth, purposeful muscle activity and movement. Disruption of these neurochemical signals, characteristic of Parkinsons disease, frequently results in involuntary movements. Drugs that increase dopamine levels are mainstay treatments for RLS, but studies have shown they dont significantly improve sleep. An estimated 5 percent of the U.S. population has RLS. ? The small new study, headed by Richard P. Allen, Ph.D., an associate professor of neurology at the Johns Hopkins University School of Medicine, used MRI to image the brain and found glutamate -- a neurotransmitter involved in arousal -- in abnormally high levels in people with RLS. The more?glutamate（谷氨酸盐）?the researchers found in the brains of those with RLS, the worse their sleep. ? The findings are published in the May issue of the journal Neurology. We may have solved the mystery of why getting rid of patients urge to move their legs doesnt improve their sleep, Allen says. We may have been looking at the wrong thing all along, or we may find that both dopamine and glutamate pathways play a role in RLS. ? For the study, Allen and his colleagues examined MRI images and recorded glutamate activity in the thalamus, the part of the brain involved with the regulation of consciousness, sleep and alertness. They looked at images of 28 people with RLS and 20 people without. The RLS patients included in the study had symptoms six to seven nights a week persisting for at least six months, with an average of 20 involuntary movements a night or more. ? The re