MAR结合蛋白及其调控功能_王天云.pdfVIP

ISSN 1007-7626 20084 CN 11-3870PQ Chinese Journal of Biochemistry and olecular Biology 24(4):302~ 306 #综述# MAR * 王天云 , 张俊河, 张 煜, 王 俐 (新乡医学院生物化学与分子生物学教研室, 河南 新乡 453003) 核基质结合区( AR) 是真核生物中能与核基质结合的DNA 片段. AR 通过与 异的 AR 结合蛋白相互作用, 在提高转基因表达水平降低转基因个体之间表达水平差异以及染色体包装等 方面具有重要的调控作用.目前,已在不同物种分离 AR 结合蛋白,分别为核基质成分核仁蛋白 组蛋白叶绿体蛋白等, 它们在调控基因表达细胞发育细胞凋亡染色体包装等方面具有重要的 功能.本文综述了目前分离出的 AR 结合蛋白及其功能,并对 AR-结合蛋白研究作一展望. 核基质结合区; 核基质; AR 结合蛋白; 调控功能 Q781 MAR-binding Proteins and their Regulatory Functions * WANGTian-Yun , ZHANGJun-He, ZHANG Yu, WANG Li (Department of Biochemistry and Molecular Bi ology , X inx iang Medical Univers ity ,X inx iang 453003, H enan , China ) Abstract atrix attachment region( AR) is the DNA sequence that binds to nuclear matrice in eukaryote organisms. AR plays important role in regulating gene expression by specific interaction with AR-binding protein tomodulatethechromosomal constructions in algae, plants, and animals. Sofar, several AR-binding proteins were isolated from human tissues and their functions in chromosome structure maintenance, cell development and apoptosis were characterized. The current understanding of AR-binding proteins and their biological functionswill be summarized inthis review. Key words matrix attachment region; nuclear matrix; AR-binding protein; regulatory function . AR , , AR , AR RNADNA , ( nuclear . matrix ). ( matrix attachment regions, , AR [2~ 4] AR)DNA : ¹ : , , AT ,