O_磷酸_L_丝氨酸及其衍生物的合成.pdfVIP

2007 27 Vol. 27, 2007 2 , 218221 Chinese Journal of Organic Chemistry No. 2, 218221 · · O--L- *,a b b b b,c (a 102205) (b 450052) (c 100084) O--L-. O--L- L-, , X ; O--L- O--L-(). . L-; O--L-; ; Synthesis of O-Phospho-L-serine and Its Derivatives ZHANG, Jian-Chen*,a CAO, Shu-Xiab ZHAO, Jun-Fengb LIAO, Xin-Chengb ZHAO, Yu-Fenb,c a ( Department of Chemical Defense, Institute of Chemical Defense, Beijing 102205) (b Key Laboratory of Organic Chemistry and Chemical Biology, Zhengzhou University, Zhengzhou 450052) (c Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biol ogy of Ministry of Education, Tsinghua University, Beijing 100084) Abstract O-Phospho-L-serine and its derivatives, having important pharmacology activity and bioactivity, were synthesized by the reaction of phosphorusoxychloride partially prehydrolyzed and L-serine. The crystal of O-phospho-L-serine was incubated and the crystal structure was determined by X-ray single crystal dif- fraction method. Furthermore, calcium salt, diisopropylamine salt and di(diisopropylamine) salt of O-phospho-L-serine were also synthesized. The structures of products were identified by NMR, IR and MS spectra. Keywords L-serine; O-phospho-L-serine; synthesis; derivative L-, . [4]; O--L- , , , .