肿瘤治疗新靶点：碱性成纤维细胞生长因子及其受体信号.pdfVIP

466 中国肿瘤临床2014年第41卷第7期 ChinJClinOncol2014,Vol.41,No.7 · · 国家基金研究进展综述 肿瘤治疗新靶点：碱性成纤维细胞生长因子及其 受体信号* 陈文慧 徐 萌 摘要 碱性成纤维细胞生长因子（bFGF）是一个促细胞分裂、增殖及血管生成的多肽生长因子，肿瘤组织中bFGF及其受体 过度表达为抗肿瘤治疗提供潜在靶目标，研制靶向性抗bFGF抗体、FGFR抑制剂等抑制肿瘤细胞增殖和新血管形成，阻断肿瘤 生长的营养和转移途径，成为抗肿瘤热点。本文就bFGF及其受体信号在肿瘤的发生、发展和转移中的作用及临床转化研究进行 综述。 关键词 bFGF FGFR 信号转导 临床转化研究 doi:10.3969/j.issn.1000-8179 New target for cancer therapy: basic fibroblast growth factor and its receptor signaling Wenhui CHEN, Meng XU Correspondence to: Meng XU; E-mail: xumengjinan@ Department of Oncology, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China. This work was supported by National High Technology Research and Development Program 863(No. 2009AA02Z 112) and Na- tional Nature Science Foundation of China (No.. Abstract Basic fibroblast growth factor (bFGF) is a kind of polypeptide that serves an important function in mitogen, prolifera- tion, and angiogenesis. bFGF is a potential anti-cancer therapy target and its receptor is highly expressed in tumor tissue. Antitumor drugs such as anti-bFGF antibody and FGFR antagonists are being developed to block tumor growth and metastasis. In this paper, bF- GF and its receptor signaling pathway in tumor development and metastasis is investigated, and clinical translational research is re- viewed. Keywords: bFGF, FGFR, signal transduction, clinical translational research 碱性成纤维生长因子（basicfibroblastgrowthfac⁃ 素型FGFs（FGF 19、21、23）和典型FGFs（FGF 1～10、 tor，bFGF）是具有促进细胞有丝分裂和诱导新血管 16～18、20）。FGF-2被命名为bFGF。bFGF（FGF-2） 生成作用的多肽，与肿瘤分化、生长、浸润、转移和肿 是一个促细胞分裂、增殖及血管生成的多肽生长因 瘤新血管生成密切相关。尽管bFGF/FGFR信号通路 子，具有修复创伤和促进再生作用，在乳腺癌、肺癌、 ［2］ 作为肿瘤治疗靶点的研究起步较