加替沙星的电化学特性及其应用.pdfVIP

JSHANXI AGRICUNIV(N atural Science Edition) ( ) 2009, 29(4) 002551 加替沙星的电化学特性及其应用 1 2 赵云芳, 张晓丽 ( 1 , 030801; 2 , 250100) : 用电化学预处理法制备了新型的玻碳电极 ( P GCE) , 并在此电极上用循环伏安法和线性扫描伏安法研 了加替沙星 ( GFLX) 的电化学特性结果表明, 在浓度为003 mol L- 1 , pH 为50 的NaA H A 缓冲溶液中, 电 压为+ 020V 条件下富集 120 s 后, GFLX 在+ 105V( vsSCE) 处产生 一个灵敏的不可逆氧化吸附峰氧化峰电流ip 与GFLX 浓度在60 10- 8 ~ 10 10- 5 mol L- 1 范围内呈良好的线性关系, 检测下限可达 10 10- 8 mol L- 1 该电极可用于直接测定尿样中加替沙星的含量, 与其他分析方法相比, 结果比较理想 : 加替沙星; 玻碳电极; 吸附伏安法 : O6571 : A : 167 1815 1 ( 2009) The electrochemical characters of Gatifloxacin and Its Analytical Application 1 2 ZHAO Yunfang , ZHANG Xiaoli (1. College of A rts and Science , S hanx i A gricultural University , T aig u Shanx i 3 8 1, China; 2 . Dep artment of Chemistry and Chemical E ngineering , S hand ong University, S handong , Jinan 25 1 , China) Abstract A new ele tro hemi ally pretreated glassy arbon ele trode ( P GCE) was fabri ated and used for the determi nation of gatiflox a in by y li and linear sw eep voltammetry. Cy li voltammetri studies indi ated that the pro ess was irreversible and fundamentally ontrolled by adsorpt ion. W ith 120 s a umulation at + 020V ( v sSCE) , a sensi t ive ox idation peak was observed at + 105V ( vsSCE) in 003 mol L- 1 pH 50 a etate buffer. T he linear range was 60 10- 8 ~ 10 10- 5 mol L- 1 . The dete tion limit was 10 10- 8 mol L- 1 . The PGCE w as applied for the di re t determination of gatif lox a in in human urine samples w ithout any pretreatment. Key words Gatiflox a in; Glassy arbon ele trode; Adsorptive voltammetry ( gatifloxa in, GFLX) , 68, 1 材料与方法