异型南五味子丁素_五味子酚和_安五脂素对血小板聚集的影响_蒋仕丽.pdfVIP

() 　Fudan Univ J Med ci 2005 Jul,32(4) 467 、(+)- ＊ ■ △ 蒋仕丽　章蕴毅 　陈道峰 ■ (, 　　200032) 【】　　3 :(heteroclitin D, HD)、(schisanhenol, AL) (+)- [(+)-anw ulignan,AN] 。　 Born , 3 0.05 ～25 mg/L (adenosine diphosphate, ADP)(platelet activating factor, PAF) 1、3、5 min 。　① HD AL ADP PAF ,AN 。② ADP 1、3、5 min , HD AL ,AN 5 mg/L 3、5 min ;PAF 1、3、 5 min , HD 1、3 min , AL 3、5 min 。③ HD、AL AN ADP PAF 。　HD、AL AN ADP PAF 。HD , 。 【】　;　;　(+)- ;　;　;　 【】　R 965.1 Effects of Heteroclitin D,Schisanhenol and (+)-Anwulignan on Platelet Aggregation ■ JIANG hi-li,ZHANG Yun-yi ,CHEN Dao-feng ■ (Department of Pharmacognosy , Department of Pharmacology, School of Pharmacy, Fudan University ,Shanghai 200032, China) 【Abstract】　Purpose　To investigate the effects of three lignans:heteroclitin D (HD),schisanhenol (AL) and (+)-anwulignan(AN )with different skeletons from chisandraceae medicinal plants on platelet aggrega- tion.　Methods　At concentrations 0.05 ～25 mg/L of the three lignans, rabbit platelet aggregation in- duced by adenosine diphosphate (ADP )and platelet activating factor (PAF )were studied by Borns tur- bidimetry,the maximum time of platelet aggregation and platelet aggregation at 1,3, 5 min were also ob- served.　Results　①HD and AL inhibited the ADP-and PAF-induced platelet aggregation in a concen- tration-dependant manner .The inhibitory effect of AN was weak.②ADP-induced pla