精氨酸生素ppt.pdfVIP

? ? ? ? ? ? ? ? ? ? ? ? ? NAG NAGP5CS CPS1 NAG NAG NAG NAG NCGNCGNAG -- ? ? nNOS— CO + NH + H O 2 3 2 iNOS— 2ATP eNOS— NAG CPS- 2ADP+Pi NO NOS PPARγ mTOR NOVEGF TLR4NFkB NOHSP70 Fig.1.Angiogenesisandvasculogenesisformingvessels: A angiogenesis:itoccursiniallywith theformaonofthebudding 1 orendothelialcelloutgrowthfollowedbystretching 2 ofsmall vesselsandbranchingbyproliferaon 3 ofexisngendothelialcellsandremodeling 4 ; B vasculogenesis:itisthegrowthofcapillariesfrompreexisngvessels 1and2 ,aerformaon ofvascular capillary tubes,theseundi?erenatedvesselsfuseformingaconnuousvascular structure 3and4 . ? ? ? ? ? ? ? ? ? ? ? mmol/l Wu1996 ? Wu2004 ? ? mTOR NO KimSWWuG 2004 JNutr134:625630 YaoKetal. 2008 138:867872 ? ? ? ? ? z p | / iz p~ $% ’ 3 34 -6 / 34 /0 ST3 / 0 5 ’ / /0i : /0 2 5 * Wu Meininger 2000 2002 F lynn 2002 * + ’ , - . ! ! /0 123 456789:; ’ # @AB/CDE@ $% % ’ * + , - . /0 4 123 456789:; 4 @AB/CDE@ ? 1 2 5 ? ? ? ? ? dothelial and endocrine cells as well as other cell types; 3 promoting the NO-mediated secretion of insulin and soma- totropin anabolic hormones ; 4 improving tissue insulin N A G FIGURE 2 Net synthesis of citrulline and arginine from glutamine panel A and postnatal changes in mitochondrial N-acetylglutamate GuoyaoWu2004 NAG concentration panel B in jejunal enterocytes of sow-reared piglets. Data are means SEM, n 6. Data for citrulline and arginine NCGP 0.01 Wu2004 ? 9 NCG50mg/kg 19 25%32% Frank2006 ? ? ? ? ? Science May 2005 Science 307; March 2005 A TB T B 35 a 30 % 25 A e t a 20 r a ab e h 15 r r a i D 10 b 5 0 1 2 3 Control Arg NCG C 120 a b a Control 0.6%Arg NCG 100 b 80 g NCGArg21 G 60 b D a A A B 40 C 20 0 Control 0.6%Arg NCG Wu Xin et al. 2009 DPP: 160 Arg NCG umol/L 283.00±8.26a 319.81±29.92b 387.49±29.02b umol/L 206.50±8.94a 222.40±4.69b 238.03±6.88b umol/L 61.63±9.29 86.11±12.08 82.34±8.92 μ mol/L 117.81±15.72 154.48±31.17 134.15±32.19 T U/mL 25.6