ChIP技术及其在基因组水平上分析DNA与蛋白质相互作用.pdfVIP

316–319 Nucleic Acids Research, 2000, Vol. 28, No. 1 © 2000 Oxford University Press TRANSFAC: an integrated system for gene expression regulation 1, 1,2 3 4 1 1,4 1 E. Wingender *, X. Chen , R. Hehl , H. Karas , I. Liebich , V. Matys , T. Meinhardt , M. Prüß1,4, I. Reuter1 and F. Schacherer1 1Gesellschaft für Biotechnologische Forschung mbH, Mascheroder Weg 1, D-38124 Braunschweig, Germany, 2The National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, People’s Republic of China, 3Technische Universität Braunschweig, Biozentrum, D-39100 Braunschweig, Germany and 4 BIOBASE GmbH, Mascheroder Weg 1B, D-38124 Braunschweig, Germany Received September 30, 1999; Accepted October 7, 1999 ABSTRACT breakthrough was achieved by linking it with TRRD (Tran- scription Regulatory Region Database) (8) and by connecting TRANSFAC is a database on transcription factors, the database COMPEL on composite regulatory elements (9). their genomic binding sites and DNA-binding profiles Additional database modules have been developed more (http://transfac.gbf.de/TRANSFAC/ ). Its content has recently, devoted to signal transduction pathways and organs/ been enhanced, in particular by information about cell types (10). In the present contribution, the status of these training sequences used for the