Wnt信号通路在SD大鼠乳腺癌发生过程中动态变化意义的探讨.pdfVIP

中华肿瘤防治杂志2008 年3 月第 15 卷第6 期 CH IN J CANCER REV TREAT , March 2008, Vol1 15 No1 6 # 401 # ×前沿报道Ø Wnt SD , , , , 华中科技大学协和医院乳腺甲状腺外科, 湖北 武汉430022 Dynamics of Wnt signaling p athway in the pr oces s of rat s car cinogenesis of breast cancer LI Zhi , LI U Chun2p in g , ZH AN G N in g , T I AN Yu an , H UAN G Ta o Dep ar tment of Br east an d Thyr oid Sur ger y , Union H osp ita , H u a zh ong Un iver sity of Science an d Techno ogy , Wuh a n 430022, P . R. Ch in a = :SD [ABSTR ACT] OBJE CTIVE : To study the dynamics of Wnt sig2 Wnt , naling pathway in the process of rats carcinogenesis of breast 。: cancer, and discuss the factors closed with the cancer2related ( DMBA) SD genes. ME TH ODS: Breast cancer was induced in SD rats with , SD DMBA, in the carcinogenesis process of dynamic access, the 4th 4 , pairs of breast tissue specimens of the SD rats were collected and Wnt the Wnt signaling pathway associated gene expression levels were mRNA 。: SD detected with gene chip technology. RESULTS: In the carcinogene2 ,Wnt2、Wnt5a、Wnt9b sis process of SD rats, Wnt2, Wnt5a, Wnt9b and Tcf3, Tel4 ex2 Tcf3、Tel4 , pressions had a gradual increase, and a significant increase occurred 4~ 6 ; A C、A C2、 from the 4th to 6th week after induced cancer; A C, A C2, DDK1, DDK1、DDK4 Wisp2 DDK4 Wisp2 expressions had a gradual reduction, and a significant , 6 。: reduction occurred in the 6th week after induced c