5%27-鸟苷酸二钠晶型转化研究的论文+.pdfVIP

5 ’-鸟苷酸二钠晶型转化研究 刘宝树 王静康 尹秋响 王如帆 (天津大学化工学院，天津300072，中国) 摘 要：5’-鸟苷酸二钠存在无定形体和晶体两种固体状态。利用在线监测手段（FBRM和PVM ）和离线 监测手段（XRD ）对5’-鸟苷酸二钠在水＋A二元溶剂体系中由无定形体转化为晶体（晶型Ⅰ）的过程进行研 究。通过对转化过程中固体颗粒粒度、形状和晶体结构变化的分析，对转化机理进行推断。结果表明，5’- 鸟苷酸二钠无定形体转化为晶体过程的机理为溶液过渡转化（SMT ），即无定形5’-鸟苷酸二钠不断溶解，而 5’-鸟苷酸二钠晶体则经历成核和成长的过程，最终无定形体全部转化为晶体。 关键词：5’-鸟苷酸二钠；无定形；晶体；转化；在线；FBRM；PVM Study on the Polymorphic Transition of 5’-GMPNa2 LIU Bao-shu ，WANG Jing-kang ，YIN Qiu-xiang ，WANG Ru-fan (School of Chemical Engineering and Technology ，Tianjin University，Tianjin 300072，China) Abstract ：5’-GMPNa exists in two solid forms: amorphous and crystalline. The 2 polymorphic transition process of 5’-GMPNa2 from amorphism to crystal (polymorphism Ⅰ) in water+A binary mixture solvents was investigated by in-situ monitoring technique( FBRM and PVM) and ex-situ monitoring technique(XRD). By tracking changes in particle sizes, shape and crystal structure in the transformation process, the transition mechanism was deduced. Results show that the polymorphic transition mechanism of amorphous 5 ’-GMPNa to crystalline 5 ’-GMPNa is solution 2 2 mediated transition(SMT). In detail, the amorphous 5’-GMPNa2 dissolves into solution continuously, then followed by the nucleation and growth of crystal. Finally, the amorphism is converted into crystal completely. Keywords ：5 ’-GMPNa ; amorphism; crystal; transition; in-situ; FBRM; PVM 2 收稿日期：2006-08-20 作者简介：刘宝树，1973 年生，河北科技大学讲师，博士在读，e-mail ：lbszrn@ 5 ’-鸟苷酸二钠是一种重要的食品添加剂及医 HO 药用品，属于第二代鲜味剂，广泛用于各类食品