6种抗菌中药对鼠疫菌抑菌作用观察.pdfVIP

·实验研究· 6种抗菌中药对鼠疫菌抑菌作用观察 薛建江李立宏乔海霞 刘进军 季建军 张玉妥杨瑞馥邱景富 【摘要】目的观察6种抗菌中药对鼠疫菌的抑菌活性作用。方法选择6种(黄连、苦参、连翘、大黄、生 地、知母)常用抗菌中药，分别采用水提法制备至质量浓度1 mg／L的药液。应用液体稀释法测定上述中药对鼠疫 菌201株与EV76株的最低抑菌浓度(MIC)。结果黄连、大黄与连翘抑制鼠疫菌的作用均较强，MIC值 00 00 均≤0．050mg／L，其中大黄的抑菌作用最强(MIC值为0．025mg／L)。同一种中药对鼠疫菌不同菌株 的MIC值相同。结论常用抗菌中药对鼠疫菌有一定的抑菌作用。 【关键词】耶尔森菌，鼠疫； 微生物敏感性试验； 抗菌药 ofsixChinese onYers／n／a Antibacteraleffect traditionalmedicines pestisXUE^吼了i彻∥，LILi—hong， Hai-xia，LIU Yu—tuo，YANG +Clinicial QIA0 Jin-jun，JlJian-jun，ZHANG Rui-fu，QIUJing-fu． Laboratoryof TheFirst North 075000，China AffilitedHosphial，HebeiCollege，Zhangiakou Correspondingauthor：QWJing-fu，Email：jfqiu@126．com ToscreentheantibacterialofChinesetraditionalmedicinesYersinia 【Abstract】OMeetive activity against SixChinese traditional Chinesisetc)wereselectedandextractedwith pestis．Methods medicines(Coptis pure watertomakeaconcentrationof1 strain201andEV76wereusedtodeterminetheminimal mg／L．Yersiniapestis theseselectedmedicinesinvitrowith dilutionmethod．ResultsThreeherbs concentrations(MIC)of inhibitory liquid hadinhibitioneffectsonthestrain201andEV76indifferent whichRheum hadthe extents，among palmatum was 00 had effectandMIC 0．025 ChinesetraditionalmedicinethesameMICon strongest mg／L．Furthermore．the bothstrain201andEV76．ConclusionsChinesetraditionalmedicines usedhave effecton commonly inhibiting Yersinia pesti． Yersinia Microbial