精氨酸血管加压素对大鼠失血性休克的作用.pdfVIP

2008 10 3 J T r um Surg, 2008, Vol. 10, No. 3 2 11 : 1009- 4237( 2008) 03- 0211- 03 李 涛, 徐 竞, 杨光明, 明 佳, 张 瑗, 陈 玮, 刘良明 ( 第三军医大学大坪医院野战外科研究所二室, 伤烧伤与复合伤国家重点实验室, 重庆 400042) : ( AVP) , ( MAP) , 24 + AVP ( 0. 1U / kg) + AVP ( 0. 4U /kg) 2 2 ( LR); + AVP ( 0. 1U /kg) + AVP( 0. 4U /kg) 2 LR AVP( 0. 1U /kg)( 0. 4U /kg) MAP , 2 LR MAP, AVP( 0. 1U /kg)( 0. 4U /kg), MAP; ( LV SP) ( dp /d t ) , AVP m x ( 0. 1U /kg)( 0. 4U /kg), 24 AVP : ; ; : R 605. 971 : A Beneficial effect ofAVP on hemorrhagic shock in rats LI Tao,XU Jing, YANG Guang-m ing, et a.l ( St te Key L bor tory ofT r um , Bu rns nd Comb ined Injury, Dep rtm ent 2, Institu te of Surgery Rese rch, D ping H ospit l, Third M ilit ry M ed i lUn iversity, Chongqing 400042, Chin ) Abstract: Objective T o investig te the benefici l effect of rginine v sopressin( AVP ) on hem orrh gic shock in r ts. M ethods H emorrh gic shock(40mmHg for 2h) ofW ist r r ts w ere dopted to observe the effects of sm ll dose of AVP onMAP, hem odyn m ics nd 24h surviv l r te. Th irty-two w ist r r tsw ere d ivided into 4 groups: norm l contro,l shock con trol, AVP 0. 1U /kg nd AVP 0. 4U /kg group. Results AVP t the concentr tion of 0. 1U /kg nd 0. 4U /kg c n sign ific ntly mi prove the hem odyn m ic p r m eters includ ing left in tr ventricul r systolic pressure( LVSP) nd the m xmi l ch nge r te of left intr ventricu l r pressure( dp/ dt m x). The 24h surviv l r te of hem orrh gic shock r tsw s incre sed follow ingAVP t 0. 1U /kg nd 0. 4U /kg. Conclusion Sm ll