细胞凋亡研究进展_李超.pdfVIP

第 29卷 第 3期 世界科技研究与发展 Vol. 29 No. 3 2007年 6月 45- 53页 W ORLD SC ITECH RD Jun. 2007 pp. 45- 53 1 1 2 2* ( 1. , 610064; 2. , 610041) : 细胞凋亡( apoptosis)是机体正常细胞在受到生理和病理性刺激后出现的一种自发的死亡过程, 是一 个 动高度有序基因控制及一系列酶参与的过程细胞凋亡在保证多细胞生物健康生存过程中扮演着关键角色, 对 个体的正常发育具有重要作用它在多细胞生物的组织分化器官发育机体稳态的维持中有着重要的意义机 体在产生新生细胞的同时, 衰老和突变的细胞通过凋亡机制而被清除, 使器官和组织得以正常地发育和代谢细 胞凋亡发生异常会导致疾病的发生,如肿瘤自身免疫性疾病病毒感染和神经退化性疾病等由于细胞凋亡的重 要意义, 它在生物进化过程中不但得到了保留, 而且从简单的多细胞生物线虫, 到高度进化的人类, 细胞凋亡机制 随着生物的进化得到了发展和完善本文概述了细胞凋亡的特征分子机制信号途径检测方法及生物学意义 : 细胞凋亡 Caspase Bcl- 2 调亡途径 检测方法 生物学功能 R esearch Advan ces on Apop tosis 1 1 2 2* L I Chao FU Shengbo L IU Hua ing M A X inrong ( 1. School ofLife Science, Sichuan University, Chengdu 610064; 2. Chengdu Institute ofBiology, CAS, Chengdu 610041) Abstrac t: Apoptosis is a spontaneous cell- suicide process triggered in response to physiological and pathological stress stmi ul.i It is an initiative, tightly regulated and gene controlled process involved in theparticipation ofa series of enzymes. Apoptosis plays akey role in the tissuedifferentiation, organ development and individualhomeostasis inmulticellularorgan isms by elmi inating redundant, damaged or infected cells. Apoptosis is associatedw ith diseases. Derangement of apoptosis results in diseases such as cancer, auto- mi munity, viral infections and neurodegenerative disease. Apoptosis exists ubiq uitously inmulticellular organisms and evolves into highlyodered process. This review focused on the characteristics, mo lecularmechanisms, detectionmethods, signal pathways, and biological significance of apoptosis. K ey word s: apoptosis, casp