肿瘤干细胞学说在非小细胞肺癌研究中的应用.pdfVIP

56 2011 1 17 1M edical Recap itulate, Jan 2011, V l. 17, N . 1 姜 尧 () , 刘雁勇, 左萍萍 () (, 100005) : R734. 2 : A : 2011) : 肿瘤干细胞学说的提出是对传统肿瘤治疗方式的巨大挑战, 研究者已在非小细胞肺癌 找到了具有干细胞特性的细胞, 并加以分离和鉴定非小细胞肺癌干细胞在癌组织的发生发展过程 起着重要作用, 并与耐药性和转移相关, 基于肿瘤干细胞的治疗策略也已逐渐成形在此主要综 述近几年在非小细胞肺癌及其干细胞研究方面的相关进展 : 肿瘤干细胞; 非小细胞肺癌; 肺癌治疗 A pplication of Cancer Stem CellTheory inR esearch of NonsmallCellLung Cancer JIAN G Yao, LIU Yanyong, ZUO P ing p ing. (D ep artm ent of Pharmacology, Instit te of B asicM edical Science ChineseA cademy , of M edical Sciences, B eij ing 100005, China) Abstract: The cancer stem cell th e ry is a b ig challenge t the traditi nal th erapy f can cer. M re and m re researchers have already f und stem like cancer cells in n nsm all cell lung cancer, w h is late and characterize th ese cells based n their features. Recent research reveals that cancer stem cell n t nly plays an mi p rtant r le in the devel pm ent and pr cess f n nsm all lung can cer, but als is ass ciated w ith drug resistan ce and m etastasis. A therapeutic regmi en targeting can cer stem cell is em erg ing. Th is article rev iew s [ 5] recent pr gress in n nsm all cell lung cancer and can cer stem cell. 1997, B nnet Keyw ords: Can cer stem cell; N nsm all cell lung cancer; Lung cancer therapy ( acu te myel cytic leukem ia, AML) [ 1] + - , 130 CD CD , 34 38 , 80% ( n nsm