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2017-08-20 发布于湖北
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Cancer immunotherapy in clinical practice-the past, present, and future.pdf

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Cancer immunotherapy in clinical practice-the past, present, and future.pdf

Cancerimmunotherapyl■ncl0in0ical■practic‘e-- thepast，present，andfuture GauravGoelandWeijingSun Abstract Considerableprogresshasbeenmade inthefieldofcancerimmunotherapy inrecentyears．This hasbeenmadepossible in largepartbythe identificationofnew immune-basedcellulartargetsand thedevelopmentofnovelapproachesaimedatstimulatingthe immunesystem．Theroleplayedby the immunosuppressivemicroenvironmentinthedevelopmentoftumorshasbeenestablished．The Successofcheckpoint-inhibitingantibodiesandcancervaccineshasmarkedthebeginningofanew era incancertreatment．Thisreview highlightstheclinicallyrelevantprinciplesofcancerimmunologyand variousimmunotherapeuticapproachesthathaveeitheralreadyenteredmainstream oncologicpractice orarecurrently intheprocessofbeingevaluatedinclinicaltrials．Furtherm0re．thecurrentbarriersto thedevelopmentofeffectiveimmunotherapiesandthepotentialstrategiesofovercomingthem arealso discussed． Keywords Cancerimmunotherapy，immunoediting，checkpointinhibitors，cancervaccines，adoptivecelltransfer Cancerlherapyisacontinuouslyevolvingfield．andnoveI anoverview ofclinicallyrelevantimmunologyandimmunotherapy immunOlheraDeuljcapproachesarenow emergingaseffective principles，andvariousimmunOlherapeulicapproachesthatarebeing freatmentoptionsagainstvariouslypesofcancers．Cancer integratedintocurrentoncologicpractice． immunOtherapVreliesOnIheprincipleofmobilizingthehosl Immunesystem tofighIagainslcancercells．Variousapproaches HistoricaIOverview havebeenattemptedduringthelaslseveraIdecadesloharness Iheinnatepowersoflheimmunesystem lofightcancer．Despite Theantitumorpotentialoftheimmunesystem hasbeen lhebeslefforts．however,onlyIimitedsuccesshasbeenachieved recognizedforaIonglime．Thefirslknownattemptlouselhe Indevelopingeffectiveantitumorimmun0lheraDjes．Theinability powe