TGF-β对毛囊生长发育影响的研究进展.pdfVIP

中国美容医学2009年2月第18卷第2期ChineseJournalofAestheticMedicine．Feb．2009．V01．18．No．2255 ·综述· TGF-D对毛囊生长发育影响的研究进展 曾东-综述，余文林1胡志奇2审校 (1．广州军区广州总医院整形外科广东广州510010；2．南方医科大学附属南A-gi院整形外科广东广州 510515) 在毛囊发育和生长周期中的作用进行综述。 [关键词]TGF-D；毛囊；生长周期 [中图分类号]Qsl3．1[文献标识码]A [文章编号】1008-6455(2009)02-0255—04 Theeffectof factoronthe and ofhairfollicle transforminggrowth p growthdevelopment ZENG Wen—linl，HU Don91，YU Zhi-qi2 ofPlastic General of 510010 (1．DepartmentSurgery，GuangzhongHospitalGuangzhouMilitaryRegion，Guangzhou of Medical 510515 Guangdong，China；2．Departmentplasticsurgery。NanfangHospital，Nanfanguniversity．Guangzhou Guangdong，China) factor tothe the Abstract；Transforminggrowth beta(TGF-IDbelongsTGF-15superfamily．Duringdevelopmentprocess ofhair their were and inhair follicle，TGF—D1，TGF一艮andreceptorsIocationallycyclicallyspecificallyexpressedfollicles， and were tobeinvolvedin the and ofhairfollicle． multiplesignallingpathwaysproved regulatinggrowthdevelopment Studiesof or knockoutof alsoconfirmedthat related was forhair transgenegene TGF—p TGF-p signallingnecessary in follicle isindicatedthat an role hair and development．It TGF-pmayplay important development the of inhair and revieweffectivenessTGF—B developmentcycle． factor；hair Keywords：transforminggrowth foIlicle；growthcycle 毛发的生长周期t要分为3个时期，即生长期、退行期 外基质形成、生长发育、机体免疫、损伤修复和肿瘤形成等多 和静J卜期。毛发的发育和周期性生长受很多因素和因于的控 种生理及病