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组 117.87±14.27 vs 90.91±8.09, P=0.001）；而血清 KLF4 则明显降低，
差异具有统计学意义（N-PVD vs 对照组 44.88±7.05 vs 53.74±7.38，
P=0.04）。结论：hsCRP、Ps 及 KLF4 在 2 型糖尿病下肢血管病变的
发生发展中具有临床价值。血清高 Ps 及 hsCRP 水平可能是 2 型糖
尿病 PAD 发病的重要危险因素，与 PAD 严重程度密切相关；而
KLF4 则可能具有延缓糖尿病下肢血管病变发生发展的作用。Ps、CRP
及 KLF4 能否作为早期糖尿病下肢血管病变发生的预测指标，KLF4
是否可作为新的防治糖尿病合并下肢血管病变的干预指标还有待进
一步的研究。
关键词：2 型糖尿病；下肢血管病变；超敏 C 反应蛋白；可溶性
P 选择素；kruppel 样因子 4
Relationship Among High-sensitivity C-reactive Protein,
soluble P-selection, Kruppel-like factor 4 and peripheral vascular
disease in Type 2 diabetes patients
Abstract
Objective:Toinvestigate the relationship Among high-sensitivity
C-reactive Protein, soluble P-selection, Kruppel-like factor 4 and
peripheral vascular
disease in Type 2 diabetes patients. Method：The
level of inflammation hctors including hsCRP，Ps，KLF4 were compared
among PVD patients(ABI0.9) , N-PVD patients(ABI≥0.9) as well as the
control group，and the differences in body mass index(BMI)，blood
pressure(BP)，serum glucofe，HbA lc, and Bloodlipid were also observed.
Result: Compared with the N-PVD group and the control group, the level
of hsCRP and Ps were both significantly incressed(the hsCRP level: PAD
vs N-PVD 77.44±8.59 vs 61.16±9.41 ， P=0.003;
PAD vs control
77.44±8.59 vs 44.48±6.15，P＜0.001. the Ps level：PAD vs N-PVD
142.42±13.46 vs 117.87±14.27，P=0.002; PAD vs control 142.42±13.46
vs 90.91±8.09，P＜0.001); however, the KLF4 level in PVD group was
significantly lower than that of N-PVD group and control group( PAD vs
N-PVD 34.72±5.41vs 44.88±7.05，P=0.019；PAD vs control 34.72±5.41
vs 53.74±7.38，P＜0.001).In addition, we found that N-PVD group had
higher level in hsCRP and Ps than control group(the hsCRP level: N-PVD
vs control 61.16±9.41 vs 44.48±6.15，P=0.002；the Ps level: N-PVD vs
control 117.87±14.27 vs 90.91±8.09, P=0.001), yet the KLF4 level was
decreased markedly in N-PVD group compared with the control
group(N-PVD vs control 44.88±7.05 vs 53.74±7.38, P=0.04). Conclusion:
hsCRP, Ps as well as KLF4 have the simil
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