慢性可变应激对大鼠强迫游泳行为的影响与海马结构的平行改变.pdfVIP

32 　6 　　　　　　(　　 ) Vol.32 No.6　 974 200611 Journal of Jilin University (Medicine Edition) Nov. 2006 　　[] 　167-1 587Ⅹ(2006)06-097-4 03 1 2 1 2 * 夏映红, 胡　冰, 孙晓霞, 赵　华 (1. , 130021; 2. , 130021) [　] 　:。: Wistar , Wistar 12 , , 6, , , CA3 。:, , , (P0.01), CA3 (P0.05)。: , , CA3 。 [] 　;, /;, ;;/ [] 　 42;R-332　　 [] 　A Effect of chronic variable stress on forced swimming test of rats and parallel changes of hippocampus structure 1 2 1 2 * XIA Ying-hong , HU Bing , SUN Xiao-xia , ZHAO Hua (1. Experimental Center of Functional Sciences, School of Basic Medical Sciences Jilin University, Changchun 130021, China; 2. Department of Physiology, School of Basic Medical Sciences, Jilin University, Changchun 130021, China) Abstract:Object ive 　To observe the effect of chronic variable stress on the forced swimming test of rats, and investigate its preliminary mechanism. Met hods　 First a mark was given to each Wistar rat by forced swimming test. 12 Wistar rats which had similar scores were selected and divided into control group and model group averagely. The behavior changes of rats were induced in the forced swimming test by chronic stress and the plasma cortisol level was analyzed through radioimmunoassay (RIA)methods. The changes of hippocampus CA3 structure were observed with microscope. Results　Compared with control group, chronic variable stress increased immobility time, reduced climbing time evidently and enhanced the weight of adrenal gland and the level of plas