可生物降解环境感应型药物控释系统地研究.pdfVIP

可生物降解环境感应型药物控释系统的研究∗ 张杰，褚良银** ，张诗博，陈文梅，王海东，巨晓洁 （四川大学化工学院，四川成都 610065 ） 摘 要：制备了基于壳聚糖和多羟基盐类化合物的凝胶给药系统，研究了其柱状凝胶和球状凝胶的制备以及 其温度和pH 双重感应性。结果表明，该系统在低于室温时呈液态，升温至 37℃左右则形成固态凝胶，并且 凝胶温度越高，凝胶强度越好。发现制备的凝胶具有pH 感应性，以VB12 为模型药物，对柱状凝胶的在不同 pH 环境下的释放特性进行了表征。在pH4.0 条件下，70min 内释放药物65 ％左右；pH7.4 下，相同时间内只 释放了57 ％左右。以改性壳聚糖为原料的凝胶释药实验表明，在pH4.0 下，柱状凝胶70min 内释放了42 ％左 右；pH7.4 下，相同时间内仅释放了 37 ％左右，降低释放速率的同时在一定程度上保持了凝胶原有的温度和 pH 复合感应性。在不同pH 环境下释药后和在生物降解前后的凝胶微观形貌有明显的差别。 关键词：壳聚糖；可生物降解；药物载体；pH 感应；温度感应；控制释放 Study on Biodegradable Environment-Sensitive Controlled-Release Systems for Drug Delivery ZHANG Jie, CHU Liangyin, ZHANG Shibo, CHEN Wenmei, WANG Haidong, JU Xiaojie (School of Chemical Engineering, Sichuan University, Chengdu 610065 , Sichuan, China) Abstract: Hydrogel drug delivery systems based on chitosan/polyol salt combinations were prepared with cylindrical and spherical shapes, and their thermo-/pH-sensitivities were investigated. The systems could be held liquid below room temperature and they formed monolithic gels at body temperature. The higher the gelling temperature was, the higher the strength of hydrogels. The study reported for the first time pH-sensitivity of the hydrogels. VB12 was taken as the model drug and the release characteristics of the prepared system were studied at various pH environments. Under pH4.0 condition, about 65% of the drug was released within 70 min; while under pH7.4 condition, about 57% released within the same time. Release experiments on hydrogels with modified chitosan were performed. Under pH4.0 condition, the hydrogel system released 42% within 70 min; while under pH7.4 condition, it only released 37% within the same time. By modifying the chitosan, the rate of release was decreased while the thermo-/pH-sensitivities were retained in a certain extent. Distinct differences of microstructures of hydrogels were found both after