恶性胸腔积液中CD4_T细胞的研究进展_宫原.pdfVIP

网络出版时间：2014-06-05 11:29 496 2014 41 5 Cancer Res Prev Treat,2014,Vol.41,No.5 · · 肿瘤防治研究 年第 卷第 期 网络出版地址：/kcms/doi/10.3971/j.issn.1000-8578.2014.05.035.html doi:10.3971/j.issn.1000-8578.2014.05.035 低分子肝素改善胰腺癌患者预后及相关机制 研究进展 周 瑾，焦 锋，蔡 讯，王理伟 Review on Low-molecular-weight Heparin in Improving Prognosis of Pancreatic Cancer ZHOU Jin, JIAO Feng, CAI Xun, WANG Liwei Department of Oncology,Shanghai Jiaotong University Affiliated Shanghai First Peoples Hospital, Shanghai 201620,China Corresponding Author:WANG Liwei,E-mail:yzwlw@ Abstract: Due to poor prognosis and low survival rate, pancreatic cancer remains a major threaten to human health. And cancer-associated thrombosis is one of the main factors infl uencing the prognosis in pancreatic cancer patients. There have been an increasing number of studies on low-molecular-weight heparin reducing the incidence of venous thrombosis, and even improving the survival of cancer patients. In this review, we briefl y summarize the progress of low-molecular-weight heparin treatment on pancreatic cancer patients and the molecular mechanism involved ． Key words: Low-molecular-weight heparin; Pancreatic cancer; Cancer-associated thrombosis; Clinical trails ：胰腺癌是严重危害人类健康的恶性肿瘤之一，预后差、生存率低。肿瘤相关性血栓事件 的发生是胰腺癌患者预后不良的主要因素。越来越多的数据表明低分子肝素（low-molecular-weight heparin, LMWH cancer-associated thrombosis ）等抗凝剂的使用可以显著降低肿瘤相关性血栓事件（ ） 的发生率，改善胰腺癌患者的生活质量甚至预后。本文就LMWH应用于胰腺癌的相关临床研究及抗 肿瘤方面的机制作一综述。 ：低分子肝素；胰腺癌；肿瘤相关性血栓事件；临床试验 R735.9 A ： ： 0 主要包括深静脉血栓、肺栓塞、弥漫性血管内凝 胰腺癌是严重危害人类健康的恶性肿瘤之一， 血、门静脉血栓和动脉血栓栓塞等[2] 。最早关于胰 13 8 [1] 发病率和死亡率分别居于世界第 位和第 位 。肿 腺癌与血栓关系的报道是在 1938年，尸检发现近 瘤相关性血栓事件（cancer