大秦艽汤抗炎作用研究.pdfVIP

AconitiPraeparataeDecoctionandtransitionalcompositioninbloodcanexertcertaintherapeuticactionofcardiacshock,andadjustenergy metabolismoftheheart. GinsengandAconitiPraeparataeDecoction(参附汤 );transmigrationcompositioninblood;cardiacshock;hemodynamics;en ergymetabolism 大秦艽汤抗炎作用研究 赵勤1胡锐2葛明娟3周利平2 1西藏民族学院，咸阳7120822陕西中医学院，咸阳7120463陕西408厂职工医院，咸阳712000 目的：研 究大秦艽汤的抗炎作用。方法：分别采用冰醋酸引起的小鼠腹腔毛细血管通透性增加、二甲苯致小鼠耳肿 胀、角叉菜胶致大鼠足趾浮肿、大鼠棉球肉芽肿等炎症动物模型研究大秦艽汤对急慢性炎症的作用。结果：大秦艽汤30g/kg，15g/ kg和7.5g/kg各剂量组均能抑制二甲苯致小鼠耳肿胀，与模型组比较有显著性差异；30g/kg和15g/kg剂量组可以降低毛细血管通 透性，吸光度值明显降低，与模型对照组比较有明显差异。大秦艽汤20g/kg,l0g/kg和5g/kg各剂量组均可抑制角叉菜胶致大鼠足 跖肿胀，与模型对照组比较，大秦艽汤20g/kg剂量组在致炎后l、2、3、6h足跖肿胀率降低均有显著性差异；大秦艽汤各剂量组棉球 肉芽肿重均较模型组大鼠低，与模型对照组比较,20g/kg剂量组有明显差异，能明显抑制大鼠棉球肉芽组织的增生。结论：实验结 果提示大秦艽汤能明显减轻实验动物的急性炎症和慢性炎症，具有明显的抗炎作用。 大秦艽汤；抗炎 Studyonanti-inflammatoryeffectofDaqinjiaotang ZhaoQin1HuRui2GeMingjuanZhouLiping2 1TibetCollegeofNationalities,Xianyang 712000;2ShaanxiUniversityofChineseMedicine,Xianyang 712046 3TheWorkerHospitalof408FactoryinShaanxi,Xianyang 712000 Objective:Tostudytheanti-inflammatoryeffectsofDaqinjiaotangthroughpharmacologicalexperiment.Methods:Fourinflamnatory animalmodelswereusedtostudytheanti-inflammationofDaqinjiaotang,includingthepermeabilityincreaseoftheabdominalcavityblood capillarybyHACinmice,theswellingofearinducedbyxyleneinmice,andcarrageenaninducedfootacuteinflammatoryedemainrat, thecottonpelletgranulomaoftherat.Results:TheDaqinjiaotangwiththedoseof30g/kg,15g/kg和 7.5g/kghassignificantanti-inflamma tionactiononearsswellinducedbyxyleneandpenetrationofcapillaryvesselinmice(p＜0.01,p＜0.05),withthedoseof20g/kgstrongin hibitionratfootswellinginducedbycarrageenanandthecottonpelletgranulomaofthemice(p＜0.01,p＜0.05).Conclusion:TheDaqin jiaotanghassignificantanti-inflammationonvariousinflammatorymodels. Daqinjiaotang(大秦丸汤);anti-inflammatory