胞磷胆碱配合遮盖治疗大龄弱视76例_医学论文.docVIP

胞磷胆碱配合遮盖治疗大龄弱视76例_医学论文 胞磷胆碱配合遮盖治疗大龄弱视76例_医学论文 【关键词】 弱视/治疗 关键词: 胞苷二磷酸胆碱弱视/治疗视力，次正常 摘 要:目的 观察胞磷胆碱配合遮盖治疗大龄弱视患者的远期疗效. 方法 弱视患者76例，年龄12～26（平均16.6±3.3）岁，接受1～3个疗程的胞二磷胆碱治疗（体质量lt40kg，500mg#12539d-1 ，体质量≥40kg，1000mg#12539d-1 ），每个疗程15d，随访3～9mo.所有患者均先进行配镜矫正.对双眼视力相差超过两行（以国际标准视力表计）的患者，连续遮盖20d后，间断遮盖每周6d，3mo为一疗程.对双眼视力相当的远视患者配合双色光闪烁弱视治疗仪治疗，双眼各15min#12539d-1 . 结果 经1～3个疗程后，80（71%）只眼视力提高在2行以上，其中36只眼（32%）提高在4行以上.停药5wk后视力均有不同程度降低，但遮盖及再次用药后仍能继续提高.坚持治疗的患者视力有波动，但趋势向好优势眼视力与弱视眼的视力均可提高视力≥5.0者视力仍可提高大剂量组疗效显著. 结论 胞磷胆碱治疗大龄弱视，其疗效显著，无明显副作用. 　　Keywords:cytidine diphosphate cholineamblyopia/therapyvision，subnormal 　　Abstract:AIM To observe the further effects of citicoline injection combined with occlusion therapy and other methods on amblyopia patients older than12years.METHODS 76amblyopia patients（aged12to26，average16.6±3.3）were given1～3courses of citicoline injection（500mg#12539d-1 for pa- tient weightlt40kg，1000mg#12539d-1 for patients with weight≥40kg），one course was15days，and followed up for3～9months.All patients were given spectacle correction at the first visit.For patients whose visual acuity（VA）differences between two eyes were more than two lines（according to in-ternational visual acuity test chart），the better seeing eye was given occlusion6d#12539wk-1 after complete occlusion for20days.Two-color-shining therapeutic apparatus were used by patients for15min#12539d-1 whose two eyes VA were somewhat equal，15days was one course.RESULTS After1～3courses treatment，80eyes（71%）obtained≥2-lines VA im-provement，and36eyes（32%）obtained≥4-lines VA en-hancement.VA would drop after drug injection was stopped for5wk，but the VA could be enhanced if occlusion and drug injection were given again.VA had some variation if treat-ments were continued，but the tendency was to better ef-fects.The VA of better seeing eyes and amblyopia eyes could enhance at the same time.Eyes with better VA≥5.0could also be improved.Large dose groups could get more signifi-cant effects.CONCLUSION The effects of citicoline on